Sign of Leser-Trélat and Cutaneous T-Cell Lymphoma: A Rare Association

Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their concl...

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Bibliographic Details
Published in:Dermatopathology (Basel, Switzerland) Switzerland), 2018-04, Vol.5 (2), p.69-73
Main Authors: André, Raphaël, Laffitte, Emmanuel, Abosaleh, Marem, Cortès, Bégonia, Toutous-Trellu, Laurence, Kaya, Gürkan
Format: Article
Language:English
Subjects:
Case Studies
Seborrheic keratosis
Sign of Leser-Trélat
T-cell lymphoma
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Summary:Sign of Leser-Trélat is a rare paraneoplastic cutaneous manifestation, characterized by the sudden appearance and rapid increase in size and number of seborrheic keratoses, accompanied by pruritus. Edmund Leser and Ulysse Trélat described this sign in 1890. Since their first description, their conclusions have been considered controversial and some authors assert the absence of a causal link. It seems to be frequently associated with solid tumors and in particular gastrointestinal cancer. Here, we describe a new case associated with a cutaneous T-cell lymphoma and a partial response to extracorporeal photopheresis.
ISSN:2296-3529
2296-3529
DOI:10.1159/000488982