Caspase-10, matrix metalloproteinase-9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The level...

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Bibliographic Details
Published in:Oncology letters 2018-08, Vol.16 (2), p.2039-2045
Main Authors: Qian, Hua, Li, Xiaoguang, Zhang, Wei, Ma, Liang, Sun, Junfeng, Tang, Xianling, Chen, Yongsheng, Teng, Lichen, Wang, Wentao, Li, Dechao, Xu, Yongpeng, Li, Changfu, Cao, Yan
Format: Article
Language:English
Subjects:
Apoptosis
Care and treatment
Development and progression
Enzyme regulation
Genetic aspects
Health aspects
Kidney cancer
Medical prognosis
Metastasis
Oncology
Pathogenesis
Patients
Proteases
Proteins
Renal cell carcinoma
Studies
Tumors
Urine
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Summary:Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase-10, MMP-9 and total LM were analyzed by ELISA in tumor tissues and adjacent non-malignant tissues of 27 patients with ccRCC. The results revealed that caspase-10 levels in the tumor tissues were significantly higher than those in the adjacent non-malignant tissues (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.8845