Caspase-10, matrix metalloproteinase-9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The level...

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Published in:Oncology letters 2018-08, Vol.16 (2), p.2039-2045
Main Authors: Qian, Hua, Li, Xiaoguang, Zhang, Wei, Ma, Liang, Sun, Junfeng, Tang, Xianling, Chen, Yongsheng, Teng, Lichen, Wang, Wentao, Li, Dechao, Xu, Yongpeng, Li, Changfu, Cao, Yan
Format: Article
Language:English
Subjects:
Apoptosis
Care and treatment
Development and progression
Enzyme regulation
Genetic aspects
Health aspects
Kidney cancer
Medical prognosis
Metastasis
Oncology
Pathogenesis
Patients
Proteases
Proteins
Renal cell carcinoma
Studies
Tumors
Urine
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container_end_page 2045
container_issue 2
container_start_page 2039
container_title Oncology letters
container_volume 16
creator Qian, Hua
Li, Xiaoguang
Zhang, Wei
Ma, Liang
Sun, Junfeng
Tang, Xianling
Chen, Yongsheng
Teng, Lichen
Wang, Wentao
Li, Dechao
Xu, Yongpeng
Li, Changfu
Cao, Yan
description Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase-10, MMP-9 and total LM were analyzed by ELISA in tumor tissues and adjacent non-malignant tissues of 27 patients with ccRCC. The results revealed that caspase-10 levels in the tumor tissues were significantly higher than those in the adjacent non-malignant tissues (P
doi_str_mv 10.3892/ol.2018.8845
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The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase-10, MMP-9 and total LM were analyzed by ELISA in tumor tissues and adjacent non-malignant tissues of 27 patients with ccRCC. The results revealed that caspase-10 levels in the tumor tissues were significantly higher than those in the adjacent non-malignant tissues (P<0.05). The MMP-9 levels in the tumor tissues were significantly lower than those in adjacent non-malignant tissues (P<0.01). The total LM levels in tumor tissues revealed no statistical difference with those in the adjacent non-malignant tissues (P=0.757). Additionally, caspase-10 levels were positively correlated with MMP-9 levels (P<0.001), but negatively correlated with total LM levels (P<0.05) in tumor tissues. Correlation analyses with clinical data of patients with ccRCC, revealed that caspase-10 levels (P<0.05) and MMP-9 levels (P<0.001) in tumor tissues were positively correlated with tumor grades of ccRCC, whereas total LM levels were positively correlated with tumor size (P<0.05). The results of the present study suggested that interactions between caspase-10, MMP-9 and LM are likely involved in the pathogenesis of ccRCC. A deeper understanding of the correlation between caspase-10, MMP-9 and LM would aid the clarification of pathogenesis of ccRCC.]]></description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.8845</identifier><identifier>PMID: 30008898</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Apoptosis ; Care and treatment ; Development and progression ; Enzyme regulation ; Genetic aspects ; Health aspects ; Kidney cancer ; Medical prognosis ; Metastasis ; Oncology ; Pathogenesis ; Patients ; Proteases ; Proteins ; Renal cell carcinoma ; Studies ; Tumors ; Urine</subject><ispartof>Oncology letters, 2018-08, Vol.16 (2), p.2039-2045</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright © 2018, Spandidos Publications 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c467t-d0f459428a05725e5eb09e0654f234dd822fcb42f5058706c21880f15205238f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036347/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036347/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30008898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qian, Hua</creatorcontrib><creatorcontrib>Li, Xiaoguang</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Ma, Liang</creatorcontrib><creatorcontrib>Sun, Junfeng</creatorcontrib><creatorcontrib>Tang, Xianling</creatorcontrib><creatorcontrib>Chen, Yongsheng</creatorcontrib><creatorcontrib>Teng, Lichen</creatorcontrib><creatorcontrib>Wang, Wentao</creatorcontrib><creatorcontrib>Li, Dechao</creatorcontrib><creatorcontrib>Xu, Yongpeng</creatorcontrib><creatorcontrib>Li, Changfu</creatorcontrib><creatorcontrib>Cao, Yan</creatorcontrib><title>Caspase-10, matrix metalloproteinase-9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description><![CDATA[Clear cell renal cell carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase-10, MMP-9 and total LM were analyzed by ELISA in tumor tissues and adjacent non-malignant tissues of 27 patients with ccRCC. The results revealed that caspase-10 levels in the tumor tissues were significantly higher than those in the adjacent non-malignant tissues (P<0.05). The MMP-9 levels in the tumor tissues were significantly lower than those in adjacent non-malignant tissues (P<0.01). The total LM levels in tumor tissues revealed no statistical difference with those in the adjacent non-malignant tissues (P=0.757). Additionally, caspase-10 levels were positively correlated with MMP-9 levels (P<0.001), but negatively correlated with total LM levels (P<0.05) in tumor tissues. Correlation analyses with clinical data of patients with ccRCC, revealed that caspase-10 levels (P<0.05) and MMP-9 levels (P<0.001) in tumor tissues were positively correlated with tumor grades of ccRCC, whereas total LM levels were positively correlated with tumor size (P<0.05). The results of the present study suggested that interactions between caspase-10, MMP-9 and LM are likely involved in the pathogenesis of ccRCC. 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The aim of the present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into the pathogenesis of ccRCC. The levels of caspase-10, MMP-9 and total LM were analyzed by ELISA in tumor tissues and adjacent non-malignant tissues of 27 patients with ccRCC. The results revealed that caspase-10 levels in the tumor tissues were significantly higher than those in the adjacent non-malignant tissues (P<0.05). The MMP-9 levels in the tumor tissues were significantly lower than those in adjacent non-malignant tissues (P<0.01). The total LM levels in tumor tissues revealed no statistical difference with those in the adjacent non-malignant tissues (P=0.757). Additionally, caspase-10 levels were positively correlated with MMP-9 levels (P<0.001), but negatively correlated with total LM levels (P<0.05) in tumor tissues. Correlation analyses with clinical data of patients with ccRCC, revealed that caspase-10 levels (P<0.05) and MMP-9 levels (P<0.001) in tumor tissues were positively correlated with tumor grades of ccRCC, whereas total LM levels were positively correlated with tumor size (P<0.05). The results of the present study suggested that interactions between caspase-10, MMP-9 and LM are likely involved in the pathogenesis of ccRCC. A deeper understanding of the correlation between caspase-10, MMP-9 and LM would aid the clarification of pathogenesis of ccRCC.]]></abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30008898</pmid><doi>10.3892/ol.2018.8845</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Apoptosis
Care and treatment
Development and progression
Enzyme regulation
Genetic aspects
Health aspects
Kidney cancer
Medical prognosis
Metastasis
Oncology
Pathogenesis
Patients
Proteases
Proteins
Renal cell carcinoma
Studies
Tumors
Urine
title Caspase-10, matrix metalloproteinase-9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma
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