Elucidating feed-forward apoptosis signatures in breast cancer datasets: Higher FOS expression associated with a better outcome

Overstimulation of pro-proliferative pathways and high level expression of pro-proliferative transcription factors (TFs) can lead to apoptosis. This is likely due to TF binding sites for pro-proliferative TFs common to pro-proliferative and pro-apoptosis-effector genes. Certain clinical datasets hav...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2018-08, Vol.16 (2), p.2757-2763
Main Authors: Fisler, Diana A, Sikaria, Dhiraj, Yavorski, John M, Tu, Yaping N, Blanck, George
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Breast cancer
Care and treatment
Cytochrome
Datasets
Development and progression
Dihydrofolate reductase
Gene expression
Genetic aspects
Genomes
Health aspects
Kinases
Proteins
Software
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Overstimulation of pro-proliferative pathways and high level expression of pro-proliferative transcription factors (TFs) can lead to apoptosis. This is likely due to TF binding sites for pro-proliferative TFs common to pro-proliferative and pro-apoptosis-effector genes. Certain clinical datasets have indicated that molecular markers associated with higher proliferation rates lead to improved outcomes for patients with cancer. These observations have been extensively assessed on a general basis, however there has been little work dissecting feed-forward apoptosis signaling pathways that may represent specific distinctions between a pro-proliferative mechanism and a pro-apoptotic mechanism in samples from patients with cancer. Using The Cancer Genome Atlas datasets and bioinformatic approaches, the present study reports that higher FOS expression levels, along with higher FOS target apoptosis-effector gene expression, is associated with an increased survival, while higher POU2F1 expression is associated with a reduced survival (average difference of 25.9 months survival). In summary, in the datasets examined FOS represents an apoptosis-driver and high POU2F1 represents a driver mechanism for cancer development.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.8957