Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment

Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of g...

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Bibliographic Details
Published in:Journal of Cancer 2018-01, Vol.9 (13), p.2334-2340
Main Authors: Ding, Mengting, Liu, Yuhan, Liao, Xinhui, Zhan, Hengji, Liu, Yuchen, Huang, Weiren
Format: Article
Language:English
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Review
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Summary:Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechanisms of eRNAs action, as well as diseases related to dysregulation of eRNAs.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.25829