Exosome-related lncRNAs as predictors of HCC patient survival: a prognostic model

Accumulating evidence suggests that long non-coding RNA (lncRNA) may affect hepatocellular carcinoma (HCC) progression. However, the mechanism remains unclear. Previous studies have shown that exosomes may promote tumor progression by transporting proteins. Our study aimed to determine the prognosti...

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Published in:American journal of translational research 2018-01, Vol.10 (6), p.1648-1662
Main Authors: Hou, Yuchen, Yu, Zheng, Tam, Nga Lei, Huang, Shanzhou, Sun, Chengjun, Wang, Rongchang, Zhang, Xuzhi, Wang, Zekang, Ma, Yi, He, Xiaoshun, Wu, Linwei
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Language:English
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Summary:Accumulating evidence suggests that long non-coding RNA (lncRNA) may affect hepatocellular carcinoma (HCC) progression. However, the mechanism remains unclear. Previous studies have shown that exosomes may promote tumor progression by transporting proteins. Our study aimed to determine the prognostic value of lncRNAs in HCC and the underlying mechanism. A dataset comprising a HCC cohort of 364 patients from The Cancer Genome Atlas (TCGA) was analyzed to identify lncRNAs with prognostic value. Co-expression and competing endogenous RNA (ceRNA) networks were constructed to investigate the mechanism of exosome-related lncRNAs. To confirm the bioinformatics analysis results, 95 pairs of clinical samples were evaluated by digoxigenin-labeled chromogenic in situ hybridization (CISH). Five lncRNAs (CTD-2116N20.1, AC012074.2, RP11-538D16.2, LINC00501 and RP11-136I14.5) with significant differences were identified (P
ISSN:1943-8141
1943-8141