Comparative Screening Analytic Methods for Elderly of Blood Methylmercury Concentration between Two Analytical Institutions

Methylmercury is widely known to be a toxic substance in the human, especially a nervous system. However, it is difficult to accurately measure the amount of methylmercury in blood, and the form of methylmercury is variously presented. The purpose of study was to compare the total mercury and methyl...

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Published in:Computational and mathematical methods in medicine 2018-01, Vol.2018 (2018), p.1-5
Main Authors: Kim, Yu-Mi, Lim, Hyoun-Ju, Sakomoto, Mineshi, Haraguchi, Koichi, Hong, Young-Seoub, Kim, Byoung-Gwon, Seo, Jeong-Wook
Format: Article
Language:English
Subjects:
Aged
Female
Hematologic Tests
Humans
Japan
Male
Methylmercury Compounds - blood
Reference Values
Republic of Korea
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Summary:Methylmercury is widely known to be a toxic substance in the human, especially a nervous system. However, it is difficult to accurately measure the amount of methylmercury in blood, and the form of methylmercury is variously presented. The purpose of study was to compare the total mercury and methylmercury measurements techniques and detection levels between analytical institutions in two countries using the same elderly human blood samples. Total mercury using gold amalgamation direct mercury analysis method (both) and methylmercury using the dithizone extraction and gas chromatography-electron capture detector (GC-ECD) method (N Lab in Japan) and the cold vapor atomic fluorescence spectrophotometer (CVAFS) method (D Lab in Korea) were measured in 47 subjects who agreed to participate in this study. Total mercury concentrations in both analytical laboratories were observed at similar levels (9.4 versus 9.5 ug/kg, p=0.898) and the distribution was highly correlated. However, the concentration of methylmercury showed some difference between two laboratories (9.1 versus 8.6 ug/kg, p
ISSN:1748-670X
1748-6718
DOI:10.1155/2018/2509413