Acoustical Emission Analysis by Unsupervised Graph Mining: A Novel Biomarker of Knee Health Status

• Published in: IEEE transactions on biomedical engineering 2018-06, Vol.65 (6), p.1291-1300
• Main Authors: Hersek, Sinan, Baran Pouyan, Maziyar, Teague, Caitlin N., Sawka, Michael N., Millard-Stafford, Mindy L., Kogler, Geza F., Wolkoff, Paul, Inan, Omer T.
• Format: Article
• Language: English
• Subjects: Acoustic emission; Acoustic measurements; Adult; Algorithms; Biomarkers; Biomedical measurement; Data Mining; Data processing; Emission analysis; Feature extraction; Female; Graph mining; Graphs; Health Status; Heterogeneity; Humans; Injuries; Knee; knee health; Knee Injuries - physiopathology; Knee Injuries - rehabilitation; Knee Joint - physiology; Male; Microphones; Range of Motion, Articular - physiology; Recovery; Recovery of function; Rehabilitation; rehabilitation engineering; Signal processing; Signal Processing, Computer-Assisted; Sound Spectrography - methods; Surgery; unsupervised learning; Wearable Electronic Devices; wearable sensing; Windows (intervals); Young Adult
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2017.2743562

Objective: To study knee acoustical emission patterns in subjects with acute knee injury immediately following injury and several months after surgery and rehabilitation. Methods: We employed an unsupervised graph mining algorithm to visualize heterogeneity of the high-dimensional acoustical emission data, and then to derive a quantitative metric capturing this heterogeneity-the graph community factor (GCF). A total of 42 subjects participated in the studies. Measurements were taken once each from 33 healthy subjects with no known previous knee injury, and twice each from 9 subjects with unilateral knee injury: first, within seven days of the injury, and second, 4-6 months after surgery when the subjects were determined to start functional activities. Acoustical signals were processed to extract time and frequency domain features from multiple time windows of the recordings from both knees, and k-nearest neighbor graphs were then constructed based on these features. Results: The GCF calculated from these graphs was found to be 18.5 ± 3.5 for healthy subjects, 24.8 ± 4.4 (p = 0.01) for recently injured, and 16.5 ± 4.7 (p = 0.01) at 4-6 months recovery from surgery. Conclusion: The objective GCF scores changes were consistent with a medical professional's subjective evaluations and subjective functional scores of knee recovery. Significance: Unsupervised graph mining to extract GCF from knee acoustical emissions provides a novel, objective, and quantitative biomarker of knee injury and recovery that can be incorporated with a wearable joint health system for use outside of clinical settings, and austere/under resourced conditions, to aid treatment/therapy.