Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies

Bone is a metabolically active tissue that renews itself throughout one’s life. Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling. Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topi...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-8
Main Authors: Akbari, Solmaz, Rasouli-Ghahroudi, Amir Alireza
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bone and Bones - physiology
Bone grafts
Bone matrix
Bone remodeling
Bone strength
Bone turnover
Calcification, Physiologic
Cell Differentiation
Coagulation
Cytokines
Differentiation
Grafting
Growth factors
Menaquinones
Mesenchyme
Metabolism
Mineralization
Osteoblastogenesis
Osteoblasts
Osteoblasts - physiology
Osteogenesis
Proteins
Review
Stem cells
Substitute bone
Systematic review
Transcription
Vitamin D
Vitamin deficiency
Vitamin K
Vitamin K - physiology
Vitamin K 2
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Summary:Bone is a metabolically active tissue that renews itself throughout one’s life. Cytokines along with several hormonal, nutritional, and growth factors are involved in tightly regulated bone remodeling. Accordingly, vitamin K as a multifunctional vitamin has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. Vitamin K exerts its anabolic effect on the bone turnover in different ways such as promoting osteoblast differentiation, upregulating transcription of specific genes in osteoblasts, and activating the bone-associated vitamin k dependent proteins which play critical roles in extracellular bone matrix mineralization. There is also credible evidence to support the effects of vitamin k2 on differentiation of other mesenchymal stem cells into osteoblast. The main objective of the present paper is to comprehensively outline the preclinical studies on the properties of vitamin K and its effects on the bone metabolism. The evidence could shed light on further clinical studies to improve osteogenesis in bone graft surgeries.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/4629383