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Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study
Excessive alcohol consumption is associated with brain aberrations, including abnormalities in frontal and limbic brain regions. In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decrea...
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Published in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2018-08, Vol.43 (9), p.1876-1883 |
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creator | Sawyer, Kayle S Maleki, Nasim Papadimitriou, George Makris, Nikos Oscar-Berman, Marlene Harris, Gordon J |
description | Excessive alcohol consumption is associated with brain aberrations, including abnormalities in frontal and limbic brain regions. In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decreases in white matter fractional anisotropy in abstinent alcoholic men. In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity and their association with alcoholism history. The dMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history. Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety. Our results suggest that sexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse. |
doi_str_mv | 10.1038/s41386-018-0089-6 |
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In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decreases in white matter fractional anisotropy in abstinent alcoholic men. In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity and their association with alcoholism history. The dMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history. Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety. Our results suggest that sexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse.</description><identifier>ISSN: 0893-133X</identifier><identifier>ISSN: 1740-634X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-018-0089-6</identifier><identifier>PMID: 29795404</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Abuse ; Adult ; Aged ; Alcohol abuse ; Alcoholic beverages ; Alcoholics ; Alcoholism ; Alcoholism - diagnostic imaging ; Anisotropy ; Attention deficit hyperactivity disorder ; Brain ; Brain - diagnostic imaging ; Brain - drug effects ; Complications ; Corpus callosum ; Diffusion Tensor Imaging ; Drug abuse ; Female ; Gender differences ; Humans ; Limbic system ; Magnetic resonance imaging ; Male ; Men ; Middle Aged ; Neural networks ; Neuroimaging ; Sex Characteristics ; Sex differences ; Sexual dimorphism ; Substantia alba ; White Matter - diagnostic imaging ; White Matter - drug effects ; Young Adult</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2018-08, Vol.43 (9), p.1876-1883</ispartof><rights>Copyright Nature Publishing Group Aug 2018</rights><rights>American College of Neuropsychopharmacology 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-8fba01bedb143d67f6bd3f598a0ef6121f0c07dbc14ca36ead43ca6caa069b43</citedby><cites>FETCH-LOGICAL-c427t-8fba01bedb143d67f6bd3f598a0ef6121f0c07dbc14ca36ead43ca6caa069b43</cites><orcidid>0000-0001-7767-5688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046037/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046037/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29795404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawyer, Kayle S</creatorcontrib><creatorcontrib>Maleki, Nasim</creatorcontrib><creatorcontrib>Papadimitriou, George</creatorcontrib><creatorcontrib>Makris, Nikos</creatorcontrib><creatorcontrib>Oscar-Berman, Marlene</creatorcontrib><creatorcontrib>Harris, Gordon J</creatorcontrib><title>Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Excessive alcohol consumption is associated with brain aberrations, including abnormalities in frontal and limbic brain regions. In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decreases in white matter fractional anisotropy in abstinent alcoholic men. In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity and their association with alcoholism history. The dMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history. Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety. Our results suggest that sexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse.</description><subject>Abuse</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol abuse</subject><subject>Alcoholic beverages</subject><subject>Alcoholics</subject><subject>Alcoholism</subject><subject>Alcoholism - diagnostic imaging</subject><subject>Anisotropy</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - drug effects</subject><subject>Complications</subject><subject>Corpus callosum</subject><subject>Diffusion Tensor Imaging</subject><subject>Drug abuse</subject><subject>Female</subject><subject>Gender differences</subject><subject>Humans</subject><subject>Limbic system</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sexual dimorphism</subject><subject>Substantia alba</subject><subject>White Matter - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawyer, Kayle S</au><au>Maleki, Nasim</au><au>Papadimitriou, George</au><au>Makris, Nikos</au><au>Oscar-Berman, Marlene</au><au>Harris, Gordon J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>43</volume><issue>9</issue><spage>1876</spage><epage>1883</epage><pages>1876-1883</pages><issn>0893-133X</issn><issn>1740-634X</issn><eissn>1740-634X</eissn><abstract>Excessive alcohol consumption is associated with brain aberrations, including abnormalities in frontal and limbic brain regions. In a prior diffusion tensor magnetic resonance imaging (dMRI) study of neuronal circuitry connecting the frontal lobes and limbic system structures, we demonstrated decreases in white matter fractional anisotropy in abstinent alcoholic men. In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity and their association with alcoholism history. The dMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history. Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety. Our results suggest that sexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>29795404</pmid><doi>10.1038/s41386-018-0089-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7767-5688</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Abuse Adult Aged Alcohol abuse Alcoholic beverages Alcoholics Alcoholism Alcoholism - diagnostic imaging Anisotropy Attention deficit hyperactivity disorder Brain Brain - diagnostic imaging Brain - drug effects Complications Corpus callosum Diffusion Tensor Imaging Drug abuse Female Gender differences Humans Limbic system Magnetic resonance imaging Male Men Middle Aged Neural networks Neuroimaging Sex Characteristics Sex differences Sexual dimorphism Substantia alba White Matter - diagnostic imaging White Matter - drug effects Young Adult |
title | Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study |
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