Associations between molecular biomarkers and MR-based cartilage composition and knee joint morphology: data from the Osteoarthritis Initiative

The purpose of this study was to assess the associations between serum/urine biomarkers for osteoarthritis and magnetic resonance (MR) imaging measures of cartilage composition and joint structure (cartilage, meniscus, and bone marrow), using MR imaging data from the Osteoarthritis Initiative (OAI)....

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Bibliographic Details
Published in:Osteoarthritis and cartilage 2018-08, Vol.26 (8), p.1070-1077
Main Authors: Joseph, G.B., Nevitt, M.C., McCulloch, C.E., Neumann, J., Lynch, J.A., Heilmeier, U., Lane, N.E., Link, T.M.
Format: Article
Language:English
Subjects:
Biomarkers - blood
Biomarkers - urine
Cartilage
Cartilage Oligomeric Matrix Protein - blood
Cartilage, Articular - diagnostic imaging
Cartilage, Articular - pathology
Collagen Type II - urine
Cross-Sectional Studies
Female
Humans
Hyaluronic Acid - blood
Knee Joint - diagnostic imaging
Knee Joint - pathology
Magnetic Resonance Imaging
Male
Matrix Metalloproteinase 3 - blood
Middle Aged
Molecular biomarkers
MRI T2
Osteoarthritis
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - pathology
Peptide Fragments - urine
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Summary:The purpose of this study was to assess the associations between serum/urine biomarkers for osteoarthritis and magnetic resonance (MR) imaging measures of cartilage composition and joint structure (cartilage, meniscus, and bone marrow), using MR imaging data from the Osteoarthritis Initiative (OAI). 141 subjects with Kellgren Lawrence (KL) grades 0–3 in the right knee and with available serum/urine biomarker assays were selected from the OAI. Cartilage magnetic resonance imaging (MRI) T2 measurements were performed in the medial femur, lateral femur, medial tibia, lateral tibia, and patella compartments. Compartment-specific knee morphologic grading [whole-organ magnetic resonance imaging score (WORMS)] in the cartilage, meniscus, and bone marrow was also performed. We focused on associations of serum hyaluronan (sHA), serum cartilage oligomeric matrix protein (sCOMP), serum matrix metalloproteinase-3 (sMMP3), and Urine Carboxy-Terminal Telepeptides of Type II Collagen (uCtX-II)) with MRI parameters (T2, WORMS), assessed using partial correlations adjusted for age, gender, body mass index (BMI), KL grade in both knees, and diabetes status. Higher levels of sHA, sMMP3 and sCOMP were correlated (P 
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2018.04.019