Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design

Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the f...

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Bibliographic Details
Published in:Pathogens and global health 2018-05, Vol.112 (3), p.123-131
Main Authors: Kazi, Ada, Chuah, Candy, Majeed, Abu Bakar Abdul, Leow, Chiuan Herng, Lim, Boon Huat, Leow, Chiuan Yee
Format: Article
Language:English
Subjects:
Animals
Computational Biology - methods
Drug Discovery - methods
Epitopes - genetics
Epitopes - immunology
Humans
Immunity, Cellular
Immunity, Humoral
Reviews
Vaccines - genetics
Vaccines - immunology
Vaccines - isolation & purification
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Summary:Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes. The ideal regions could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. At present, epitope-based vaccines are attractive concepts which have been successfully trailed to develop vaccines which target rapidly mutating pathogens. In this article, we provide an overview of the current progress of immunoinformatics and their applications in the vaccine design, immune system modeling and therapeutics.
ISSN:2047-7724
2047-7732
DOI:10.1080/20477724.2018.1446773