Erythrocyte membrane fatty acid profile & serum cytokine levels in patients with non-alcoholic fatty liver disease

• Published in: Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2018-04, Vol.147 (4), p.352-360
• Main Authors: Amirkalali, Bahareh, Sohrabi, Masoud, Esrafily, Ali, Jalali, Mahmoud, Gholami, Ali, Hosseinzadeh, Payam, Keyvani, Hossein, Shidfar, Farzad, Zamani, Farhad
• Format: Article
• Language: English
• Subjects: Body mass index; Cross-Sectional Studies; Cytokines; Drugs; Erythrocyte Membrane - chemistry; Erythrocytes; Family medical history; Fatty acids; Fatty Acids - metabolism; Fatty Acids, Omega-3; Fatty liver; Female; Gene expression; Hormones; Humans; Iran; Liver; Liver diseases; Male; Metabolism; Non-alcoholic Fatty Liver Disease; Original; Pathogenesis; Physiological aspects; Polyunsaturated fatty acids; Studies; Tumor necrosis factor-TNF; Ultrasonic imaging; Womens health
• ISSN: 0971-5916
• DOI: 10.4103/ijmr.IJMR_1065_16

Background & objectives: Fatty acids may affect the expression of genes, and this process is influenced by sex hormones. Cytokines are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), so this study was aimed to assess the association of erythrocyte membrane fatty acids with three cytokines and markers of hepatic injury in NAFLD patients and to explore whether these associations were the same in both sexes. Methods: In this cross-sectional study, 62 consecutive patients (32 men and 30 women) with NAFLD during the study period. Tumour necrosis factor-α (TNF-α), interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), aspartate aminotransferase and alanine aminotransferase were measured in a fasting serum sample, and Fibroscan was conducted for each individual. Gas chromatography was used to measure erythrocyte membrane fatty acids. Univariate and multiple linear regressions were used to analyze data. Results: In men, IL-6 had a significant (P