Oxidative stress as a possible pathogenic cofactor of post-menopausal osteoporosis: Existing evidence in support of the axis oestrogen deficiency-redox imbalance-bone loss

Post-menopausal osteoporosis (PO) is one of the major health issues associated with menopause-related oestrogen withdrawal. Despite the intense research and the relevant progress achieved in the last two decades, the pathogenic mechanism underlying PO is still poorly understood. As a consequence of...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2018-04, Vol.147 (4), p.341-351
Main Authors: Bonaccorsi, Gloria, Piva, Isabella, Greco, Pantaleo, Cervellati, Carlo
Format: Article
Language:English
Subjects:
Aged
Antioxidants
Complications and side effects
Cytokines
Estrogen
Estrogens
Female
Fruits
Homeostasis
Humans
Menopause
Metabolism
Osteoporosis
Osteoporosis, Postmenopausal - physiopathology
Oxidation-Reduction
Oxidative Stress
Physiological aspects
Review
Risk factors
Tumor necrosis factor-TNF
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Summary:Post-menopausal osteoporosis (PO) is one of the major health issues associated with menopause-related oestrogen withdrawal. Despite the intense research and the relevant progress achieved in the last two decades, the pathogenic mechanism underlying PO is still poorly understood. As a consequence of this gap in the knowledge, such disorder and the related complications are still difficult to be effectively prevented. A wealth of experimental and epidemiological/clinical evidence suggests that the endocrine change associated to menopausal transition might lead to a derangement of redox homeostasis, that is, the prelude to the health-threaten condition of oxidative stress (OxS). In turn, this (bio)chemical stress has been widely hypothesized to contribute, most likely in synergy with inflammation, to the development of menopause-related diseases, including PO. The main aim of this review is to discuss the current literature evidence on the association between post-menopausal oestrogen withdrawal, OxS and PO. It is also aimed to provide a critical overview of the most significant epidemiological studies on the effects of dietary antioxidants on bone health and to devise a strategy to overcome the limitations emerged and controversial results.
ISSN:0971-5916
DOI:10.4103/ijmr.IJMR_524_18