Dynamic Patterns of Brain Structure-Behavior Correlation Across the Lifespan

Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variat...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2017-07, Vol.27 (7), p.3586-3599
Main Authors: Razlighi, Qolamreza R, Oh, Hwamee, Habeck, Christian, O'Shea, Deirdre, Gazes, Elaine, Eich, Teal, Parker, David B, Lee, Seonjoo, Stern, Yaakov
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Brain - diagnostic imaging
Brain - physiology
Brain Mapping
Cognition - physiology
Female
Healthy Volunteers
Humans
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Male
Memory, Episodic
Middle Aged
Neuropsychological Tests
Original
Reading
Verbal Behavior
Young Adult
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Summary:Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variations on the spatial patterns of cortical thickness correlates of four cognitive domains. We showed that the spatial distribution of the cortical thickness correlates of each cognitive domain is distinctive and depicts varying age-association differences across the adult lifespan. Specifically, the present study provides evidence that distinct cognitive domains are associated with unique structural patterns in three adulthood periods: Early, middle, and late adulthood. These findings suggest a dynamic interaction between multiple neural substrates supporting each cognitive domain across the adult lifespan.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhw179