The innate immune response to RSV: Advances in our understanding of critical viral and host factors

Highlights • Innate RSV control involves the coordinated action of various cellular processes. • These processes include cell stress, death, and innate immune responses. • RSV utilizes multiple mechanisms to evade the host responses. • RSV DVGs are the primary triggers of innate immunity in mice and...

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Bibliographic Details
Published in:Vaccine 2017-01, Vol.35 (3), p.481-488
Main Authors: Sun, Yan, López, Carolina B
Format: Article
Language:English
Subjects:
Allergy and Immunology
Defective viral genomes
Host-Pathogen Interactions
Humans
Immunity, Innate
Innate immunity
NS1 and NS2 degradasome
Respiratory syncytial virus
Respiratory Syncytial Virus, Human - immunology
Viral recognition
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Summary:Highlights • Innate RSV control involves the coordinated action of various cellular processes. • These processes include cell stress, death, and innate immune responses. • RSV utilizes multiple mechanisms to evade the host responses. • RSV DVGs are the primary triggers of innate immunity in mice and humans. • New evidence suggests a critical role of DVGs in RSV pathogenesis.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.09.030