Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?

• Published in: Heart and vessels 2018-08, Vol.33 (8), p.893-900
• Main Authors: Sponder, Michael, Campean, Ioana-Alexandra, Emich, Michael, Fritzer-Szekeres, Monika, Litschauer, Brigitte, Graf, Senta, Dalos, Daniel, Strametz-Juranek, Jeanette
• Format: Article
• Language: English
• Subjects: Adult; Advanced glycosylation end products; Age; Aged; Bicycles; Biomarkers - blood; Biomedical Engineering and Bioengineering; Body mass; Cardiac Surgery; Cardiology; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - physiopathology; Clinical trials; Enzyme-Linked Immunosorbent Assay; Exercise; Exercise - physiology; Exercise Test; Female; Follow-Up Studies; Glycation End Products, Advanced - blood; Glycosylation; Humans; Inflammation; Inflammation - blood; Inflammation Mediators - blood; Lipoproteins; Male; Medical research; Medicine; Medicine & Public Health; Middle Aged; NCT; NCT02097199; Original; Original Article; Physical activity; Prospective Studies; Receptor for Advanced Glycation End Products - blood; Regression analysis; Serum levels; Time Factors; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-018-1125-5

There is growing evidence that low levels of the circulating soluble receptor of advanced glycation end products (sRAGE) are a valuable predictor of cardiovascular disease (CVD). The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. sRAGE was measured at baseline and after 2/6/8 months by ELISA. Backwards, multiple linear regression analysis was performed to investigate the association of co-variables age, sex, BMI, and performance at baseline, HbA 1 c, and lipoprotein a with baseline sRAGE levels. We identified BMI and lipoprotein a as significant predictors for baseline sRAGE levels. Compared to subjects with a performance gain ≤ 4.9% subjects with a gain > 5% showed a significant increase in sRAGE levels up to 22%. sRAGE serum levels correlate negatively with lipoprotein a levels and BMI and long-term physical activity leads to a significant increase in serum sRAGE levels (9–22%), whereby the sRAGE increase is most pronounced in subjects with initially low-performance levels, suggesting that in particular, these subject profit the most from increased physical activity. The sport-mediated increase of sRAGE might be a sign of decreased AGE-mediated inflammation and highlight the protective effect of sports on CVD and other disease which are at least partly mediated by an increased inflammation status. Clinical trials registration NCT02097199.