HLA-C06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis

Psoriasis vulgaris (PsV) is a common, chronic skin disease with a complex genetic and environmental etiology. We investigated, in 461 psoriatic patients and 454 healthy controls, the associations with psoriasis of four single-nucleotide polymorphisms (SNPs) from the psoriasis susceptibility 1 ( PSOR...

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Bibliographic Details
Published in:Molecular genetics and genomics : MGG 2018-08, Vol.293 (4), p.957-966
Main Authors: Wiśniewski, Andrzej, Matusiak, Łukasz, Szczerkowska-Dobosz, Aneta, Nowak, Izabela, Kuśnierczyk, Piotr
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Alleles
Animal Genetics and Genomics
Biochemistry
Biomedical and Life Sciences
Etiology
Female
Genetic Predisposition to Disease
Genotypes
Glycoproteins - genetics
Haplotypes
Histocompatibility antigen HLA
HLA-C Antigens - genetics
Human Genetics
Humans
Intercellular Signaling Peptides and Proteins
Life Sciences
Male
Microbial Genetics and Genomics
Middle Aged
Original
Original Article
Plant Genetics and Genomics
Polymorphism
Polymorphism, Single Nucleotide
Proteins - genetics
Psoriasis
Psoriasis - genetics
Psoriasis vulgaris
RNA, Long Noncoding
Severity of Illness Index
Sex Characteristics
Single-nucleotide polymorphism
Skin diseases
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Summary:Psoriasis vulgaris (PsV) is a common, chronic skin disease with a complex genetic and environmental etiology. We investigated, in 461 psoriatic patients and 454 healthy controls, the associations with psoriasis of four single-nucleotide polymorphisms (SNPs) from the psoriasis susceptibility 1 ( PSORS1 ) interval: rs1062470 ( PSORS1C1 / CDSN ), rs887466 ( PSORS1C3 ), rs2894207 and rs10484554 ( LOC105375015 ). The minor alleles of three SNPs (rs1062470A, rs2894207C and rs10484554T) strongly increased the disease risk (OR = 2.17, p  
ISSN:1617-4615
1617-4623
DOI:10.1007/s00438-018-1435-4