Kinase Inhibitors: The Reality Behind the Success

Tremendous progress has been made by utilizing kinase inhibitors in oncology, and these agents continue to pave the way into other areas of medicine. There are, however, many challenges to the application of kinase inhibitors due to inherent shortcomings of the drugs and lack of comprehensive unders...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2017-11, Vol.102 (5), p.726-730
Main Authors: Jeon, Jae Yoon, Sparreboom, Alex, Baker, Sharyn D.
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis - drug effects
Carcinogenesis - metabolism
Carcinogenesis - pathology
Humans
Imatinib Mesylate - pharmacology
Imatinib Mesylate - therapeutic use
Medical Oncology - methods
Medical Oncology - trends
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - pathology
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
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Summary:Tremendous progress has been made by utilizing kinase inhibitors in oncology, and these agents continue to pave the way into other areas of medicine. There are, however, many challenges to the application of kinase inhibitors due to inherent shortcomings of the drugs and lack of comprehensive understanding of tumor and disease biology. The future fate of kinase inhibitors, however, is bright, as evidenced from ongoing efforts to increase their efficacy while remediating their weaknesses in order to provide the best quality of care to patients.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.815