Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent

The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial ef...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Song, Jiang, Deng, Zhirui, Yi, Jialin, Niu, Bing, Lin, Wenshu, Chen, Qin
Format: Article
Language:English
Subjects:
Animals
Antimicrobial agents
Biodegradation
Biomedical research
Corrosion
Crosslinked polymers
Deoxyribonucleic acid
Disinfectants
Disinfectants - pharmacology
Disinfectants - toxicity
DNA
E coli
Escherichia coli
Experiments
Female
Glutaral - pharmacology
Glutaral - toxicity
Glutaraldehyde
Hazardous materials
Infections
Laboratory animals
Lymphoma
Lymphomas
Metals
Methenamine
Mice
Microbiomes
Microorganisms
Quaternary Ammonium Compounds - pharmacology
Quaternary Ammonium Compounds - toxicity
Skin
Steel
Surfactants
Systematic review
Toxicity
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD’s bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK+/− cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/9814209