Mesoporous Silicon Particles Favor the Induction of Long-Lived Humoral Responses in Mice to a Peptide-Based Vaccine

Vaccinology faces the challenge of developing improved immunization approaches that are able to induce long-term immunity with the desired Th profile according to the pathology. In this context, new vehicles for efficient antigen delivery that exert adjuvant effects play a critical role in addressin...

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Bibliographic Details
Published in:Materials 2018-06, Vol.11 (7), p.1083
Main Authors: Navarro-Tovar, Gabriela, Rocha-García, Denisse, Wong-Arce, Alejandra, Palestino, Gabriela, Rosales-Mendoza, Sergio
Format: Article
Language:English
Subjects:
Adsorption
Biocompatibility
Biomedical materials
Dendritic cells
Immunity
Immunization
Immunotherapy
Ligands
Nanoparticles
Particle size
Peptides
Physiology
Pore size
Porous materials
Proteins
Silicon
Statistical analysis
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Summary:Vaccinology faces the challenge of developing improved immunization approaches that are able to induce long-term immunity with the desired Th profile according to the pathology. In this context, new vehicles for efficient antigen delivery that exert adjuvant effects play a critical role in addressing this goal. Herein, mesoporous silicon particles (PSiP) were assessed as carriers for a peptide-based vaccine targeting the receptor for advanced glycation end products (RAGE), which is a relevant receptor in Alzheimer´s disease and other diseases. A RAGE peptide was adsorbed onto PSiP (PSiP vaccine) and administered to BALB/c mice, leading to immune responses that were similar in magnitude to those induced by the soluble peptide. However, the response induced by PSiP lasted for a significantly longer period when compared with the behavior of the group immunized with the peptide alone. Therefore, PSiP are proposed as carriers to enhance immune memory, which is critical in vaccination. This study opens interesting perspectives related to the application of PSiP in vaccinology.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma11071083