Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains

Phenolic compounds constitute one of the most promising and ubiquitous groups with many biological activities. Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective o...

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Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Wąsik, Tomasz J., Korzeniowski, Konrad, Idzik, Danuta, Wojtyczka, Robert D., Miklasińska-Majdanik, Maria, Kępa, Małgorzata, Smoleń-Dzirba, Joanna
Format: Article
Language:English
Subjects:
Acids
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents
Antibacterial activity
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Caffeic acid
Caffeic Acids - pharmacology
Cefoxitin
Clindamycin
Drug resistance
Drug resistance in microorganisms
Drug Synergism
Erythromycin
Flow cytometry
Humans
Methicillin
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Minimum inhibitory concentration
Molecular weight
Multidrug resistance
Pathogens
Phenolic compounds
Phenols
Phytochemicals
Skin
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus infections
Staphylococcus infections
Strains (organisms)
Supplements
Vancomycin
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creator Wąsik, Tomasz J.
Korzeniowski, Konrad
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Miklasińska-Majdanik, Maria
Kępa, Małgorzata
Smoleń-Dzirba, Joanna
description Phenolic compounds constitute one of the most promising and ubiquitous groups with many biological activities. Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective of the presented study was to assess the antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus reference and clinical strains isolated from infected wounds. The caffeic acid tested in the presented study showed diverse effects on S. aureus strains with the minimum inhibitory concentration (MIC) varied from 256 μg/mL to 1024 μg/mL. The supplementation of Mueller-Hinton agar (MHA) with 1/4 MIC of CA resulted in augmented antibacterial effect of erythromycin, clindamycin, and cefoxitin and to the lesser extent of vancomycin. The observed antimicrobial action of CA seemed to be rather strain than antibiotic dependent. Our data support the notion that CA alone exerts antibacterial activity against S. aureus clinical strains and has capacity to potentiate antimicrobial effect in combination with antibiotics. The synergy between CA and antibiotics demonstrates its potential as a novel antibacterial tool which could improve the treatment of intractable infections caused by multidrug-resistant strains.
doi_str_mv 10.1155/2018/7413504
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Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective of the presented study was to assess the antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination against Staphylococcus aureus reference and clinical strains isolated from infected wounds. The caffeic acid tested in the presented study showed diverse effects on S. aureus strains with the minimum inhibitory concentration (MIC) varied from 256 μg/mL to 1024 μg/mL. The supplementation of Mueller-Hinton agar (MHA) with 1/4 MIC of CA resulted in augmented antibacterial effect of erythromycin, clindamycin, and cefoxitin and to the lesser extent of vancomycin. The observed antimicrobial action of CA seemed to be rather strain than antibiotic dependent. Our data support the notion that CA alone exerts antibacterial activity against S. aureus clinical strains and has capacity to potentiate antimicrobial effect in combination with antibiotics. The synergy between CA and antibiotics demonstrates its potential as a novel antibacterial tool which could improve the treatment of intractable infections caused by multidrug-resistant strains.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/7413504</identifier><identifier>PMID: 30105241</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Anti-Bacterial Agents - pharmacology ; Anti-Infective Agents ; Antibacterial activity ; Antibiotics ; Antimicrobial agents ; Bacteria ; Bacterial infections ; Caffeic acid ; Caffeic Acids - pharmacology ; Cefoxitin ; Clindamycin ; Drug resistance ; Drug resistance in microorganisms ; Drug Synergism ; Erythromycin ; Flow cytometry ; Humans ; Methicillin ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Molecular weight ; Multidrug resistance ; Pathogens ; Phenolic compounds ; Phenols ; Phytochemicals ; Skin ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus infections ; Staphylococcus infections ; Strains (organisms) ; Supplements ; Vancomycin</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Małgorzata Kępa et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Małgorzata Kępa et al. 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subjects Acids
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents
Antibacterial activity
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Caffeic acid
Caffeic Acids - pharmacology
Cefoxitin
Clindamycin
Drug resistance
Drug resistance in microorganisms
Drug Synergism
Erythromycin
Flow cytometry
Humans
Methicillin
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Minimum inhibitory concentration
Molecular weight
Multidrug resistance
Pathogens
Phenolic compounds
Phenols
Phytochemicals
Skin
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus infections
Staphylococcus infections
Strains (organisms)
Supplements
Vancomycin
title Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains
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