Genome engineering for CNS injury and disease

[Display omitted] •Current literature on genome engineering for CNS disease and injury is reviewed.•Genome editing enables investigation of specific CNS tissue regions or cell types.•Genetically modified reprogrammed cells are valuable as tools in CNS disease models.•CNS development and disease prog...

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Bibliographic Details
Published in:Current opinion in biotechnology 2018-08, Vol.52, p.89-94
Main Authors: Pardieck, Jennifer, Sakiyama-Elbert, Shelly
Format: Article
Language:English
Subjects:
Animals
Central Nervous System - injuries
Central Nervous System Diseases - pathology
Gene Editing
Genetic Engineering - methods
Genome
Humans
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Summary:[Display omitted] •Current literature on genome engineering for CNS disease and injury is reviewed.•Genome editing enables investigation of specific CNS tissue regions or cell types.•Genetically modified reprogrammed cells are valuable as tools in CNS disease models.•CNS development and disease progression can be studied in vitro using organoids. Recent developments in genome engineering methods have advanced our knowledge of central nervous system (CNS) function in both normal health and following disease or injury. This review discusses current literature using gene editing tools in CNS disease and injury research, such as improving viral-mediated targeting of cell populations, generating new methods for genome editing, reprogramming cells into CNS cell types, and using organoids as models of development and disease. Readers may gain inspiration for continuing research into new genome engineering methods and for therapies for CNS applications.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2018.03.001