Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats

Quinone derivatives like 2-(4-hydroxyphenyl) amino-1,4-naphthoquinone (Q7) are used as antitumor agents usually associated with adverse effects on the cardiovascular system. The objective of this study was to evaluate the cardioprotective effect of ascorbate on Q7-induced cardiovascular response in...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-11
Main Authors: Paredes, Adrián, Barría, Iván, Vega, José Luis, Cifuentes, Fredi, Nwokocha, Chukwuemeka R., Benites, Julio, Sandoval, Juan Marcelo, Ortiz, Mirko, Salas, Felipe, Ayavire, Fernando, Fonseca, José Miguel, Palacios, Javier, Zavala, Ewaldo
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants
Ascorbic Acid - pharmacology
Ascorbic Acid - therapeutic use
Bioavailability
Blood pressure
Blood Pressure - drug effects
Blood vessels
Cancer therapies
Cardiomyocytes
Cell culture
Coronary vessels
Dilatation
Drugs
Ethylenediaminetetraacetic acid
Experiments
Female
Free radicals
Hydrogen peroxide
Laboratory animals
Lipid peroxidation
Male
Naphthoquinones - metabolism
Nitric oxide
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Rodents
Sapropterin dihydrochloride
Superoxide
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Summary:Quinone derivatives like 2-(4-hydroxyphenyl) amino-1,4-naphthoquinone (Q7) are used as antitumor agents usually associated with adverse effects on the cardiovascular system. The objective of this study was to evaluate the cardioprotective effect of ascorbate on Q7-induced cardiovascular response in Wistar rats. In this study, blood pressure, vascular reactivity, and intracellular calcium fluxes were evaluated in cardiomyocytes and the rat aorta. We also measured oxidative stress through lipid peroxidation (TBARS), superoxide dismutase- (SOD-) like activity, and H2O2 generation. Oral treatment of rats with ascorbate (500 mg/kg) for 20 days significantly (p
ISSN:1942-0900
1942-0994
DOI:10.1155/2018/8989676