Comparison between transoral laser surgery and radiotherapy in the treatment of early glottic cancer: A systematic review and meta-analysis

A therapeutic decision in the treatment of Tis/T1a glottic carcinoma with radiotherapy (RT) or transoral laser surgery (TOS) is still an open issue. Oncologic outcome and voice quality may support the choice for the latter To conduct a systematic review and meta-analysis to compare oncologic and fun...

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Bibliographic Details
Published in:Scientific reports 2018-08, Vol.8 (1), p.11900-7, Article 11900
Main Authors: Guimarães, André Vicente, Dedivitis, Rogério Aparecido, Matos, Leandro Luongo, Aires, Felipe Toyama, Cernea, Claudio Roberto
Format: Article
Language:English
Subjects:
692/1807/1809
692/308/2779/777
692/4028/546
692/699/67/1536
Cancer
Humanities and Social Sciences
Larynx
Laser surgery
Meta-analysis
multidisciplinary
Patients
Preservation
Radiation therapy
Science
Science (multidisciplinary)
Self evaluation
Self-assessment
Statistical analysis
Surgery
Survival
Systematic review
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Summary:A therapeutic decision in the treatment of Tis/T1a glottic carcinoma with radiotherapy (RT) or transoral laser surgery (TOS) is still an open issue. Oncologic outcome and voice quality may support the choice for the latter To conduct a systematic review and meta-analysis to compare oncologic and functional outcomes of TOS and RT as treatment options for Tis/T1a glottic cancer. Literature research on online databases was carried out. Potentially eligible articles were reviewed. Relevant articles were selected and evaluated. There was statistical significance favoring patients initially treated with TOS when it comes to overall survival, disease-specific survival and larynx preservation. No difference in local control was found. TMF, Jitter and Shimmmer measurements presented statistically significant results in favor of RT. Self-assessment of voice quality (VHI) and f0 showed no statistically significant differences. Maximum Phonation Time (MPT) had a better response to RT. There is a trend in favor of RT. Tis/T1a glottic cancer patients submitted to TOS had significant overall and disease specific survival and had fewer risks of having a total laryngectomy, when compared to the radiotherapy group. The self-assessment of voice quality and f0 did not show any difference; however, Jitter , Shimmer and MPT measurements favored radiotherapy.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-30218-x