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How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy?
Aims The purpose of the present study is to determine the overall and disease-related accuracy of clinical and radiological diagnosis when compared to the histology result of the surgical orbital biopsy. Methods A retrospective case notes analysis of patients who underwent surgical orbital biopsy du...
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| Published in: | Eye (London) 2018-08, Vol.32 (8), p.1329-1333 |
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| creator | Koukkoulli, A. Pilling, J. D. Patatas, K. El-Hindy, N. Chang, B. Kalantzis, G. |
| description | Aims
The purpose of the present study is to determine the overall and disease-related accuracy of clinical and radiological diagnosis when compared to the histology result of the surgical orbital biopsy.
Methods
A retrospective case notes analysis of patients who underwent surgical orbital biopsy during a 12-year period involving more than 100 orbital lesions. The accuracy of clinical and radiological diagnosis was compared with histological diagnosis.
Results
A total of 112 orbital biopsies were carried out in 104 eyes of 101 patients between 2003 and 2015. Correct diagnosis was reached in |
| doi_str_mv | 10.1038/s41433-018-0078-3 |
| format | article |
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The purpose of the present study is to determine the overall and disease-related accuracy of clinical and radiological diagnosis when compared to the histology result of the surgical orbital biopsy.
Methods
A retrospective case notes analysis of patients who underwent surgical orbital biopsy during a 12-year period involving more than 100 orbital lesions. The accuracy of clinical and radiological diagnosis was compared with histological diagnosis.
Results
A total of 112 orbital biopsies were carried out in 104 eyes of 101 patients between 2003 and 2015. Correct diagnosis was reached in <50% of cases by both ophthalmologists and radiologists alike. Vascular lesions exhibit characteristic clinical and imaging features that allow for accurate diagnosis and can often be managed conservatively. The greatest challenge, both clinically and on imaging was in differentiating between inflammatory and haematological orbital lesions which represented half of our cases. There was no operative mortality and there were no post-operative complications recorded.
Conclusion
Surgical orbital biopsy is a safe and accurate diagnostic tool for orbital lesions of unknown aetiology and, in our opinion, remains the gold standard.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-018-0078-3</identifier><identifier>PMID: 29615781</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/698/1688/512/2613 ; 692/699/3161 ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Biopsy - methods ; Child ; Child, Preschool ; Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Infant ; Infant, Newborn ; Inflammation ; Laboratory Medicine ; Magnetic Resonance Imaging - methods ; Male ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmologic Surgical Procedures - methods ; Ophthalmology ; Orbit - diagnostic imaging ; Orbit - surgery ; Orbital Diseases - diagnosis ; Orbital Diseases - surgery ; Pharmaceutical Sciences/Technology ; Reproducibility of Results ; Retrospective Studies ; Surgery ; Surgical Oncology ; Tomography, X-Ray Computed - methods ; Young Adult</subject><ispartof>Eye (London), 2018-08, Vol.32 (8), p.1329-1333</ispartof><rights>The Royal College of Ophthalmologists 2018</rights><rights>Copyright Nature Publishing Group Aug 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-9d4115c590dc47f6a507bde6d64d85e6a0af5b2a8518be33031c1a8f659a594b3</citedby><cites>FETCH-LOGICAL-c470t-9d4115c590dc47f6a507bde6d64d85e6a0af5b2a8518be33031c1a8f659a594b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085353/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085353/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29615781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koukkoulli, A.</creatorcontrib><creatorcontrib>Pilling, J. D.</creatorcontrib><creatorcontrib>Patatas, K.</creatorcontrib><creatorcontrib>El-Hindy, N.</creatorcontrib><creatorcontrib>Chang, B.</creatorcontrib><creatorcontrib>Kalantzis, G.</creatorcontrib><title>How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy?</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Aims
The purpose of the present study is to determine the overall and disease-related accuracy of clinical and radiological diagnosis when compared to the histology result of the surgical orbital biopsy.
Methods
A retrospective case notes analysis of patients who underwent surgical orbital biopsy during a 12-year period involving more than 100 orbital lesions. The accuracy of clinical and radiological diagnosis was compared with histological diagnosis.
Results
A total of 112 orbital biopsies were carried out in 104 eyes of 101 patients between 2003 and 2015. Correct diagnosis was reached in <50% of cases by both ophthalmologists and radiologists alike. Vascular lesions exhibit characteristic clinical and imaging features that allow for accurate diagnosis and can often be managed conservatively. The greatest challenge, both clinically and on imaging was in differentiating between inflammatory and haematological orbital lesions which represented half of our cases. There was no operative mortality and there were no post-operative complications recorded.
Conclusion
Surgical orbital biopsy is a safe and accurate diagnostic tool for orbital lesions of unknown aetiology and, in our opinion, remains the gold standard.</description><subject>692/698/1688/512/2613</subject><subject>692/699/3161</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Biopsy - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Laboratory Medicine</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmologic Surgical Procedures - methods</subject><subject>Ophthalmology</subject><subject>Orbit - diagnostic imaging</subject><subject>Orbit - surgery</subject><subject>Orbital Diseases - diagnosis</subject><subject>Orbital Diseases - surgery</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Young Adult</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kV1rFTEQhoMo9lj9Ad5IwBtvViefm71RSqlWKHij4F2YzWZPU3I2x2S30n_fHLetH-BNAu88884MLyEvGbxlIMy7IpkUogFmGoDWNOIR2TDZ6kZJJR-TDXQKGs759yPyrJQrgFps4Sk54p1mqjVsQ5bz9JOic0vG2dNQ6HzpqYthCg4jxWmgGYeQYtr-Evw1xgXnkCaaRppyH-aqRl-qUmiYqEu7PeZQKjAnWpa89t2TfUj7cvPhOXkyYiz-xd1_TL59PPt6et5cfPn0-fTkonGyhbnpBsmYcqqDoQqjRgVtP3g9aDkY5TUCjqrnaBQzvRcCBHMMzahVh6qTvTgm71ff_dLv_OD8NGeMdp_DDvONTRjs35UpXNpturYajBJKVIM3dwY5_Vh8me0uFOdjxMmnpVgOnLVCSGkq-vof9CotearnVcpoLuvLKsVWyuVUSvbjwzIM7CFUu4Zqa6j2EKo9LPHqzyseOu5TrABfgVJL09bn36P_73oLtUuvIg</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Koukkoulli, A.</creator><creator>Pilling, J. D.</creator><creator>Patatas, K.</creator><creator>El-Hindy, N.</creator><creator>Chang, B.</creator><creator>Kalantzis, G.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180801</creationdate><title>How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy?</title><author>Koukkoulli, A. ; Pilling, J. D. ; Patatas, K. ; El-Hindy, N. ; Chang, B. ; Kalantzis, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-9d4115c590dc47f6a507bde6d64d85e6a0af5b2a8518be33031c1a8f659a594b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/698/1688/512/2613</topic><topic>692/699/3161</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Biopsy - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inflammation</topic><topic>Laboratory Medicine</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Ophthalmologic Surgical Procedures - methods</topic><topic>Ophthalmology</topic><topic>Orbit - diagnostic imaging</topic><topic>Orbit - surgery</topic><topic>Orbital Diseases - diagnosis</topic><topic>Orbital Diseases - surgery</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koukkoulli, A.</creatorcontrib><creatorcontrib>Pilling, J. D.</creatorcontrib><creatorcontrib>Patatas, K.</creatorcontrib><creatorcontrib>El-Hindy, N.</creatorcontrib><creatorcontrib>Chang, B.</creatorcontrib><creatorcontrib>Kalantzis, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koukkoulli, A.</au><au>Pilling, J. D.</au><au>Patatas, K.</au><au>El-Hindy, N.</au><au>Chang, B.</au><au>Kalantzis, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy?</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>32</volume><issue>8</issue><spage>1329</spage><epage>1333</epage><pages>1329-1333</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Aims
The purpose of the present study is to determine the overall and disease-related accuracy of clinical and radiological diagnosis when compared to the histology result of the surgical orbital biopsy.
Methods
A retrospective case notes analysis of patients who underwent surgical orbital biopsy during a 12-year period involving more than 100 orbital lesions. The accuracy of clinical and radiological diagnosis was compared with histological diagnosis.
Results
A total of 112 orbital biopsies were carried out in 104 eyes of 101 patients between 2003 and 2015. Correct diagnosis was reached in <50% of cases by both ophthalmologists and radiologists alike. Vascular lesions exhibit characteristic clinical and imaging features that allow for accurate diagnosis and can often be managed conservatively. The greatest challenge, both clinically and on imaging was in differentiating between inflammatory and haematological orbital lesions which represented half of our cases. There was no operative mortality and there were no post-operative complications recorded.
Conclusion
Surgical orbital biopsy is a safe and accurate diagnostic tool for orbital lesions of unknown aetiology and, in our opinion, remains the gold standard.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29615781</pmid><doi>10.1038/s41433-018-0078-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0950-222X 1476-5454 |
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| source | Open Access: PubMed Central; Springer Nature |
| subjects | 692/698/1688/512/2613 692/699/3161 Adolescent Adult Aged Aged, 80 and over Biopsy Biopsy - methods Child Child, Preschool Diagnosis Diagnosis, Differential Female Humans Infant Infant, Newborn Inflammation Laboratory Medicine Magnetic Resonance Imaging - methods Male Medical diagnosis Medicine Medicine & Public Health Middle Aged Ophthalmologic Surgical Procedures - methods Ophthalmology Orbit - diagnostic imaging Orbit - surgery Orbital Diseases - diagnosis Orbital Diseases - surgery Pharmaceutical Sciences/Technology Reproducibility of Results Retrospective Studies Surgery Surgical Oncology Tomography, X-Ray Computed - methods Young Adult |
| title | How accurate is the clinical and radiological evaluation of orbital lesions in comparison to surgical orbital biopsy? |
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