Strain, Diet, and Gender Influence the Role of miR155 in Diabetes Mellitus

[5],[6] Miller et al. found that miR155 knockout mice in C57BL/6 background developed increased hepatic steatosis in comparison to wild-type mice when they were fed high-fat diet. Another study by Gaudet et al. reported that miR155 knockout female mice in C57BL/6 background were protected from high-...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2018-07, Vol.22 (4), p.570-572
Main Authors: Padmanaban, V, Prakash, S S
Format: Article
Language:English
Subjects:
Care and treatment
Development and progression
Diabetes
Diabetes mellitus
Gender
Gene expression
Genetic aspects
Glucose
Health aspects
Immunology
Insulin resistance
Letters to the Editor
Metabolic disorders
MicroRNA
Obesity
Rodents
Studies
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Summary:[5],[6] Miller et al. found that miR155 knockout mice in C57BL/6 background developed increased hepatic steatosis in comparison to wild-type mice when they were fed high-fat diet. Another study by Gaudet et al. reported that miR155 knockout female mice in C57BL/6 background were protected from high-fat diet-induced obesity but not male mice. The same authors studied the effect of high-fat diet in miR155 knockout animals (in C57BL/6 background) and found that insulin sensitivity was better among these mice compared to control mice fed with high-fat diet.
ISSN:2230-8210
2230-9500
DOI:10.4103/ijem.IJEM_125_18