Adiponectin, Omentin, Ghrelin, and Visfatin Levels in Obese Patients with Severe Obstructive Sleep Apnea

Objectives. Obstructive sleep apnea (OSA) is closely associated with obesity, insulin resistance, and inflammation. Adiponectin, omentin, ghrelin, and visfatin are adipokines involved in insulin sensitivity or regulation of inflammatory disease. This study aims to clarify the relationship between OS...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-8
Main Authors: Zhong, Xu, Gong, Fengying, Huang, Rong, Pang, Xing-long, Zhang, Dong-mei, Xiao, Yi
Format: Article
Language:English
Subjects:
Adipocytes
Adiponectin
Adiponectin - blood
Adolescent
Adult
Aged
Airway management
Apnea
Biochemistry
Blood pressure
Body mass index
Body weight
C-reactive protein
Case-Control Studies
China
Cholesterol
Continuous Positive Airway Pressure
Cytokines - blood
Diabetes
Diagnostic systems
Eye movements
Ghrelin
Ghrelin - blood
GPI-Linked Proteins - blood
High density lipoprotein
Hormones
Humans
Hypertension
Insulin
Insulin resistance
Laboratories
Lectins - blood
Male
Medical research
Medicine, Experimental
Middle Aged
Nicotinamide Phosphoribosyltransferase - blood
Obesity
Obesity - complications
Obesity - metabolism
Overweight
Parameters
Patients
Plasma
Proteins
REM sleep
Respiratory tract
Sleep
Sleep apnea
Sleep apnea syndromes
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - metabolism
Sleep disorders
Software
Type 2 diabetes
Young Adult
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Summary:Objectives. Obstructive sleep apnea (OSA) is closely associated with obesity, insulin resistance, and inflammation. Adiponectin, omentin, ghrelin, and visfatin are adipokines involved in insulin sensitivity or regulation of inflammatory disease. This study aims to clarify the relationship between OSA and associated adipokines. Patients and Methods. Thirty overweight male patients with severe OSA and twenty controls underwent standard diagnostic polysomnography (PSG), and 10 patients underwent overnight continuous positive airway pressure (CPAP) treatment. Blood samples were collected in the morning after PSG or CPAP procedures. Results. Among the investigated adipokines, only plasma omentin levels of patients with OSA were significantly lower than those of control subjects (442.94 ± 191.89 ng/ml versus 573.52±228.67 ng/ml, p=0.034) and levels did not change after CPAP treatment. In patients with OSA, omentin levels were positively correlated with high-density lipoprotein cholesterol (HDL) levels (r=0.378, p=0.007), adiponectin levels (r=0.709, p
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/3410135