Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects

Intestinal absorption of the water-soluble vitamins biotin and pantothenic acid is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene). We recently observed that intestinal-specific (conditional) knockout of the mouse Slc5a6 gene (SMVT-cKO)...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2018-07, Vol.315 (1), p.C73-C79
Main Authors: Sabui, Subrata, Kapadia, Rubina, Ghosal, Abhisek, Schneider, Michael, Lambrecht, Nils W G, Said, Hamid M
Format: Article
Language:English
Subjects:
Biotin
Death & dying
Dietary supplements
Drinking water
Growth rate
Inflammation
Intestinal absorption
Lactation
Large intestine
Mucosa
Pantothenic acid
Permeability
Pregnancy
Rapid Report
Rodents
Sodium
Vitamins
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Summary:Intestinal absorption of the water-soluble vitamins biotin and pantothenic acid is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT; product of the SLC5A6 gene). We recently observed that intestinal-specific (conditional) knockout of the mouse Slc5a6 gene (SMVT-cKO) is associated with growth retardation, the development of spontaneous and severe inflammation, abnormal histology in the large intestine, altered gut permeability, and early death. Our aim in this study was to examine the possibility that biotin and pantothenic acid oversupplementation (BPS) of the SMVT-cKO mice could reverse the above-described abnormalities. BPS was provided in the drinking water to mice before conception, to dams during pregnancy and lactation, and to the SMVT-cKO mice throughout their life. Our findings showed that such a regimen prevents early death, as well as normalizes the growth rate, intestinal integrity, pathology, and inflammation in SMVT-cKO mice. These findings provide clear evidence for a role for biotin and/or pantothenic acid in the maintenance of normal intestinal integrity and health.
ISSN:0363-6143
1522-1563
DOI:10.1152/ajpcell.00319.2017