Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats

Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase in the treatment of cerebral ischemia in rat model were investigated. Ninety rats were selected to establish cerebral ischemia model. Animal models were randomly divided into observation group and control group...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-08, Vol.16 (2), p.891-895
Main Authors: Li, Baoshan, Geng, Shouke, Dai, Yuanli
Format: Article
Language:English
Subjects:
Analysis
Aspirin
Brain damage
Care and treatment
Carotid arteries
Cerebral ischemia
Comparative analysis
Health aspects
Interventional radiography
Ischemia
Medical imaging
Medical prognosis
Mortality
Rats
Standard deviation
Statistical analysis
Substance abuse treatment
Treatment outcome
Values
Veins & arteries
Velocity
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Summary:Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase in the treatment of cerebral ischemia in rat model were investigated. Ninety rats were selected to establish cerebral ischemia model. Animal models were randomly divided into observation group and control group, with 45 rats in each group. Rats in observation group were treated with vascular intervention, and control group was treated with aspirin combined with defibrase. Peak systolic velocity (Vs) and end-diastolic velocity (Vd) were compared between two groups before and after 12 months of treatment. Therapeutic effects were compared before and after 6 months, and before and after 12 months of treatment. Vs and Vd of vascular lesions in observation group at 12 months were reduced after treatment, and were significantly lower than those in control group (p
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6271