Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak

Questions remain as to whether an unnoticed Ebola outbreak occurred in Guinea before the 2014-2016 epidemic. To address this, we used a highly sensitive and specific Luminex-based assay for Ebola virus (EBOV) antibody detection to screen blood samples collected in the framework of the Demographic He...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2018-01, Vol.99 (2), p.425-427
Main Authors: Keita, Alpha K, Butel, Christelle, Thaurignac, Guillaume, Diallo, Aminata, Nioke, Talla, Traoré, Falaye, Koivogui, Lamine, Peeters, Martine, Delaporte, Eric, Ayouba, Ahidjo
Format: Article
Language:English
Subjects:
Ebola virus
Emerging diseases
Epidemics
Human health and pathology
Infectious diseases
Life Sciences
Santé publique et épidémiologie
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Summary:Questions remain as to whether an unnoticed Ebola outbreak occurred in Guinea before the 2014-2016 epidemic. To address this, we used a highly sensitive and specific Luminex-based assay for Ebola virus (EBOV) antibody detection to screen blood samples collected in the framework of the Demographic Health Survey performed in 2012 in Guinea. One sample (GF069) of 1,483 tested was positive at very high immunoglobulin G titer to Zaire EBOV in Guinée Forestière. Thus, at least 2 years before the 2014 EVD outbreak in Guinea, Zaire EBOV was circulating in rural areas of this country.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.18-0105