Cardiac structure and function with and without metabolic syndrome: the Echocardiographic Study of Latinos (Echo-SOL)

ObjectiveWe assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL).MethodsNon-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic sy...

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Published in:BMJ open diabetes research & care 2018-08, Vol.6 (1), p.e000484-e000484
Main Authors: Burroughs Peña, Melissa, Swett, Katrina, Schneiderman, Neil, Spevack, Daniel M, Ponce, Sonia G, Talavera, Gregory A, Kansal, Mayank M, Daviglus, Martha L, Cai, Jianwen, Hurwitz, Barry E, Llabre, Maria M, Rodriguez, Carlos J
Format: Article
Language:English
Subjects:
Blood pressure
Body mass index
Cardiology
Cardiovascular and Metabolic Risk
Cardiovascular disease
Coronary vessels
Diabetes
Health risk assessment
Heart attacks
Heart failure
Hispanic Americans
Hypertension
Medical imaging
Metabolic syndrome
Mortality
Obesity
Population
Systematic review
Task forces
Ultrasonic imaging
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Summary:ObjectiveWe assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL).MethodsNon-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used adjusting for multiple potential confounding variables. Additional analysis was stratified according to the presence/absence of obesity (body mass index (BMI) ≥25 kg/m2) and the presence/absence of metabolic syndrome.ResultsWithin Echo-SOL, 1260 individuals met inclusion criteria (59% female; mean age 55.2 years). Compared with individuals without metabolic syndrome, those with metabolic syndrome had lower medial and lateral E′ velocities (−0.4 cm/s, (SE 0.1), p=0.0002; −0.5 cm/s (0.2), p=0.02, respectively), greater E/E′ (0.5(0.2), p=0.01) and worse two-chamber left ventricular longitudinal strain (0.9%(0.3), p=0.009), after adjusting for potential confounding variables. Increased left ventricular mass index (9.8 g/m2 (1.9), p
ISSN:2052-4897
2052-4897
DOI:10.1136/bmjdrc-2017-000484