Analysis of melanoma recurrence following a negative sentinel lymph node biopsy

Little attention has been paid to the characteristics and outcomes of patients who experience distant, local or regional recurrence of melanoma following a negative sentinel lymph node biopsy. This article aims to review the published literature on the topic and presents some general summaries regar...

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Bibliographic Details
Published in:Melanoma management 2015-08, Vol.2 (3), p.285-294
Main Authors: Hodges, Maggie, Jones, Edward, Jones, Teresa, Pearlman, Nathan, Gajdos, Csaba, Kounalakis, Nicole, McCarter, Martin
Format: Article
Language:English
Subjects:
false-negative rate
melanoma
outcomes
recurrence
sentinel lymph node
survival
Systematic Review
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Summary:Little attention has been paid to the characteristics and outcomes of patients who experience distant, local or regional recurrence of melanoma following a negative sentinel lymph node biopsy. This article aims to review the published literature on the topic and presents some general summaries regarding this patient population. Patients who experience a disease recurrence following a negative sentinel lymph node biopsy have a worse overall survival compared with patients with a positive sentinel lymph node biopsy. The implications and possible explanations for these findings are discussed in order to both underscore the need for in-depth investigation of local, regional or distant melanoma recurrence among patients following a true negative sentinel lymph node biopsy, as well as increased efforts to minimize the rate of false negative sentinel lymph node biopsies.
ISSN:2045-0885
2045-0893
DOI:10.2217/mmt.15.19