The diagnostic and prognostic value of plasma microRNA-125b-5p in patients with multiple myeloma

Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microa...

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Bibliographic Details
Published in:Oncology letters 2018-09, Vol.16 (3), p.4001-4007
Main Authors: Jiang, Yanxia, Luan, Yajing, Chang, Hong, Chen, Guoan
Format: Article
Language:English
Subjects:
Age
Biological markers
Biomarkers
Cancer therapies
Care and treatment
Development and progression
Females
Gene expression
Genetic aspects
Health aspects
Identification and classification
Medical diagnosis
Medical prognosis
MicroRNA
MicroRNAs
Multiple myeloma
Patients
Studies
Tumors
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Summary:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was used, which identified 8 upregulated miRNAs and 4 downregulated miRNAs in the plasma of 6 patients with MM compared with 6 healthy individuals. Based on the microarray results, the 8 miRNAs (miR-125b-5p, miR-483-3p, miR-4326, miR-6894-3p, miR-4498, miR-490-3p, miR-7155-5p and miR-937-3p), which were notably upregulated in MM patients were chosen for a second clinical study in 20 healthy controls and 35 patients with MM using reverse transcription- quantitative polymerase chain reaction. Receiver operating characteristic analysis demonstrated that miR-125b-5p and miR-490-3p displayed considerable diagnostic accuracy for MM with areas under the curve of 0.954 (P0.05). In summary, miR-125b-5p may serve as a potential clinical biomarker for MM.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9128