Prognostic impact of SET domain-containing protein 8 and protein arginine methyltransferase 5 in patients with hepatocellular carcinoma following curative resection

Histone methyltransferases are important determinants of the initiation and progression of hepatocellular carcinoma (HCC) and represent promising therapeutic targets. However, whether the expression profile of multiple histone methyltransferases represents a poorer prognosis is entirely unknown. The...

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Bibliographic Details
Published in:Oncology letters 2018-09, Vol.16 (3), p.3665-3673
Main Authors: Lin, Zhifei, Jia, Huliang, Hong, Liang, Zheng, Yahui, Shao, Weiqin, Ren, Xudong, Zhu, Wenwei, Lu, Lu, Lu, Ming, Zhang, Jubo, Chen, Jinhong
Format: Article
Language:English
Subjects:
Antigens
Care and treatment
Cell cycle
Development and progression
Epigenetics
Gene expression
Genetic aspects
Health aspects
Hepatitis
Hepatocellular carcinoma
Innovations
Liver cancer
Medical prognosis
Metastasis
Methyltransferases
Molecular targeted therapy
Mortality
Oncology
Patients
Phenotypes
Proteins
Statistical analysis
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Summary:Histone methyltransferases are important determinants of the initiation and progression of hepatocellular carcinoma (HCC) and represent promising therapeutic targets. However, whether the expression profile of multiple histone methyltransferases represents a poorer prognosis is entirely unknown. The aim of the present study was to investigate the association between histone methylation and HCC phenotype, and the prognostic value of combining expression levels of SET domain-containing protein 8 (SET8) with protein arginine methyltransferase 5 (PRMT5) in patients with HCC following curative resection. The retrospective study included 195 consecutive patients who had undergone hepatectomy for HCC. Immunohistochemical staining for SET8 and PRMT5 was performed on paraffin-embedded tumor tissue microarrays. Expression was analyzed for correlations with clinicopathological features, marker co-expression and patients' survival by univariate and multivariate analyses. Positive SET8 expression was noted in 104 patients (53.3%), and was associated with PRMT5 expression (n=106, 54.4%, P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9083