Skp2 expression has different clinicopathological and prognostic implications in lung adenocarcinoma and squamous cell carcinoma

High expression of S-phase kinase associated protein 2 (Skp2) is associated with numerous clinicopathological parameters, including histology, lymph node metastasis, smoking status, differentiation and Tumor-Node-Metastasis stage in non-small cell lung cancer (NSCLC). Skp2 protein is overexpressed i...

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Bibliographic Details
Published in:Oncology letters 2018-09, Vol.16 (3), p.2873-2880
Main Authors: Zhong, Kaize, Yang, Fan, Han, Qiuying, Chen, Jing, Wang, Jun
Format: Article
Language:English
Subjects:
Analysis
Bioinformatics
Breast cancer
Care and treatment
Colorectal cancer
Development and progression
Gene expression
Genetic aspects
Health aspects
Histology
Kinases
Lung cancer
Lymphatic system
Medical prognosis
Melanoma
Metastasis
Multivariate analysis
Mutation
Non-small cell lung cancer
Oncology
Pancreatic cancer
Phosphotransferases
Prostate cancer
Protein expression
Proteins
Smoking
Squamous cell carcinoma
Studies
Surgery
Tumors
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Summary:High expression of S-phase kinase associated protein 2 (Skp2) is associated with numerous clinicopathological parameters, including histology, lymph node metastasis, smoking status, differentiation and Tumor-Node-Metastasis stage in non-small cell lung cancer (NSCLC). Skp2 protein is overexpressed in lung squamous cell carcinoma (LUSC), compared with lung adenocarcinoma (LUAD), whilst the clinicopathological and prognostic implications in LUAD or LUSC remain unclear. A larger study is required to assess the differences in Skp2 expression between these NSCLC types. In the present study, the clinicopathological features and immunohistochemical expression of the Skp2 protein were studied in 500 patients with NSCLC (351 with LUAD and 149 with LUSC). Survival analyses were performed using Kaplan-Meier method and Cox regression model. Skp2 associated genes were identified based on the data from The Cancer Genome Atlas database. Skp2 was overexpressed in patients with LUSC, compared with LUAD (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9000