Characterization of the Placenta in the Newborn with Congenital Heart Disease: Distinctions Based on Type of Cardiac Malformation

The placenta is a complex organ that influences prenatal growth and development, and through fetal programming impacts postnatal health and well-being lifelong. Little information exists on placental pathology in the presence of congenital heart disease (CHD). Our objective is to characterize the pl...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric cardiology 2018-08, Vol.39 (6), p.1165-1171
Main Authors: Rychik, Jack, Goff, Donna, McKay, Eileen, Mott, Antonio, Tian, Zhiyun, Licht, Daniel J., Gaynor, J. William
Format: Article
Language:English
Subjects:
Analysis
Blood clot
Cardiac Surgery
Cardiology
Congenital heart disease
Diseases
Genetic disorders
Heart diseases
Infants (Newborn)
Medicine
Medicine & Public Health
Original
Original Article
Physiological aspects
Pregnant women
Thrombosis
Vascular Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The placenta is a complex organ that influences prenatal growth and development, and through fetal programming impacts postnatal health and well-being lifelong. Little information exists on placental pathology in the presence of congenital heart disease (CHD). Our objective is to characterize the placenta in CHD and investigate for distinctions based on type of malformation present. Placental pathology from singleton neonates prenatally diagnosed and delivered at > 37 weeks gestation was analyzed. Placental findings of absolute weight, placental weight-to-newborn birth weight ratio, chorangiosis, villus maturity, thrombosis, and infarction were recorded and analyzed based on four physiological categories of CHD: (1) single ventricle-aortic obstruction, (2) single ventricle-pulmonic obstruction, (3) two-ventricle anomalies, and (4) transposition of the great arteries (TGA). Associations between fetal Doppler assessments of middle cerebral/umbilical arterial flow and placental findings were investigated. A total of 120 cases of complex CHD were analyzed. Overall placental-to-birth weight ratios were
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-018-1876-x