Intestinal microbiota: a novel perspective in colorectal cancer biotherapeutics

It is believed that genetic factors, immune system dysfunction, chronic inflammation, and intestinal microbiota (IM) dysbiosis contribute to the pathogenesis of colorectal cancer (CRC). The beneficial role played by the direct regulation of IM in inflammatory bowel disease treatment is identified by...

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Bibliographic Details
Published in:OncoTargets and therapy 2018-01, Vol.11, p.4797-4810
Main Authors: Ding, Chenbo, Tang, Wendong, Fan, Xiaobo, Wu, Guoqiu
Format: Article
Language:English
Subjects:
Analysis
Anti-inflammatory agents
Bacteria
Biomarkers
Cancer therapies
Cancer treatment
Carcinogens
Chemotherapy
Clinical trials
Colorectal cancer
Development and progression
DNA damage
Epidemiology
Feces
Gastrointestinal diseases
Immune response
Immune system
Immunotherapy
Inflammation
Inflammatory bowel disease
Medical prognosis
Medicine
Melanoma
Metabolites
Metastasis
Microbiota
Microbiota (Symbiotic organisms)
Mortality
Pathogenesis
Prebiotics
Probiotics
Radiation therapy
Radiotherapy
Review
Studies
Therapeutics
Tumorigenesis
Tumors
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Summary:It is believed that genetic factors, immune system dysfunction, chronic inflammation, and intestinal microbiota (IM) dysbiosis contribute to the pathogenesis of colorectal cancer (CRC). The beneficial role played by the direct regulation of IM in inflammatory bowel disease treatment is identified by the decreased growth of harmful bacteria and the increased production of anti-inflammatory factors. Interestingly, gut microbiota has been proven to inhibit tumor formation and progression in inflammation/carcinogen-induced CRC mouse models. Recently, evidence has indicated that IM is involved in the negative regulation of tumor immune response in tumor microenvironment, which then abolishes or accelerates anticancer immunotherapy in several tumor animals. In clinical trials, a benefit of IM-based CRC therapies in improving the intestinal immunity balance, epithelial barrier function, and quality of life has been reported. Meanwhile, specific microbiota signature can modulate host's sensitivity to chemo-/radiotherapy and the prognosis of CRC patients. In this review, we aim to 1) summarize the potential methods of IM-based therapeutics according to the recent results; 2) explore its roles and underlying mechanisms in combination with other therapies, especially in biotherapeutics; 3) discuss its safety, deficiency, and future perspectives.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S170626