Prediction of Ewing Sarcoma treatment outcome using attenuated tissue reflection FTIR tissue spectroscopy

Ewing sarcoma is the second most common type of primary bone cancer and predominantly affects children and young people. Improved outcome prediction is key to delivering risk-adjusted, appropriate and effective care to cancer patients. Advances in the Fourier Transform Infrared (FTIR) spectroscopy o...

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Bibliographic Details
Published in:Scientific reports 2018-08, Vol.8 (1), p.12299-8, Article 12299
Main Authors: Chaber, Radosław, Łach, Kornelia, Arthur, Christopher J., Raciborska, Anna, Michalak, Elżbieta, Ciebiera, Krzysztof, Bilska, Katarzyna, Drabko, Katarzyna, Cebulski, Józef
Format: Article
Language:English
Subjects:
631/67/1344
692/4028/67/1344
Biopsy
Bone cancer
Children
Ewing's sarcoma
Ewings sarcoma
Fourier transforms
Humanities and Social Sciences
multidisciplinary
Patients
Risk factors
Sarcoma
Science
Science (multidisciplinary)
Spectroscopy
Spectrum analysis
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Summary:Ewing sarcoma is the second most common type of primary bone cancer and predominantly affects children and young people. Improved outcome prediction is key to delivering risk-adjusted, appropriate and effective care to cancer patients. Advances in the Fourier Transform Infrared (FTIR) spectroscopy of tissues enable it to be a non-invasive method to obtain information about the biochemical content of any biological sample. In this retrospective study, attenuated tissue reflection FTIR spectroscopy of biopsy samples from paediatric patients reveals spectral features that are diagnostic for Ewing Sarcoma. Furthermore, our results suggest that spectral features such as these may be of value for the prediction of treatment outcome independent to well-known, routinely used risk factors.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-29795-8