Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression

The initiation and progression of liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are dependent on its tumor microenvironment. Immune cells are key players in the liver cancer microenvironment and show complicated crosstalk with cancer cells. Emerging evidence h...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2018-08, Vol.24 (31), p.3500-3512
Main Authors: Zhang, Qi, Lou, Yu, Bai, Xue-Li, Liang, Ting-Bo
Format: Article
Language:English
Subjects:
Review
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Summary:The initiation and progression of liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are dependent on its tumor microenvironment. Immune cells are key players in the liver cancer microenvironment and show complicated crosstalk with cancer cells. Emerging evidence has shown that the functions of immune cells are closely related to cell metabolism. However, the effects of metabolic changes of immune cells on liver cancer progression are largely undefined. In this review, we summarize the recent findings of immunometabolism and relate these findings to liver cancer progression. We also explore the translation of the understanding of immunometabolism for clinical use.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v24.i31.3500