Uncommon manifestations of Vitamin B12 deficiency

[1],[2] The vitamin is involved in the proliferation, maturation, and regeneration of neural cells. Deficiency of cyanocobalamin leads to accumulation of methylmalonyl-CoA and homocysteine in the serum,[2] which are risk factors for coronary artery disease. In our country, many big cities do not hav...

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Bibliographic Details
Published in:Indian journal of psychiatry 2018-04, Vol.60 (2), p.255-257
Main Authors: Mohapatra, Rabindra, Pradhan, Sudhi, Kumari, Pushpa
Format: Article
Language:English
Subjects:
Acids
Cardiovascular disease
Coronary artery
Hair
Letters to Editor
Vitamin B
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Summary:[1],[2] The vitamin is involved in the proliferation, maturation, and regeneration of neural cells. Deficiency of cyanocobalamin leads to accumulation of methylmalonyl-CoA and homocysteine in the serum,[2] which are risk factors for coronary artery disease. In our country, many big cities do not have laboratory facilities to estimate serum level of total vitB12 and folic acid, so, we suggest, peripheral smear showing evidence of megaloblastic changes and symptoms of vitB12 deficiency should prompt the clinician to start treatment with parenteral vitB12 to prevent irreversible neuropsychiatric changes, however blood sample may be collected for vitB12 and folic acid estimation before that.
ISSN:0019-5545
1998-3794
DOI:10.4103/psychiatry.IndianJPsychiatry_164_11