Biochemical control systems for small molecule damage in plants

As a system, plant metabolism is far from perfect: small molecules (metabolites, cofactors, coenzymes, and inorganic molecules) are frequently damaged by unwanted enzymatic or spontaneous reactions. Here, we discuss the emerging principles in small molecule damage biology. We propose that plants evo...

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Bibliographic Details
Published in:Plant signaling & behavior 2018-01, Vol.13 (5), p.e1477906-e1477906
Main Authors: Hüdig, M., Schmitz, J., Engqvist, M. K. M., Maurino, V. G.
Format: Article
Language:English
Subjects:
Abiotic stress
enzyme promiscuity
glyoxalase system
metabolic intermediates
Mini-Review
molecule damage
Oxidative Stress - physiology
Plants - metabolism
reactive carbonyl species
reactive oxygen species
Reactive Oxygen Species - metabolism
repair system
scavenging systems
small molecules
steering systems
Stress, Physiological - physiology
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Summary:As a system, plant metabolism is far from perfect: small molecules (metabolites, cofactors, coenzymes, and inorganic molecules) are frequently damaged by unwanted enzymatic or spontaneous reactions. Here, we discuss the emerging principles in small molecule damage biology. We propose that plants evolved at least three distinct systems to control small molecule damage: (i) repair, which returns a damaged molecule to its original state; (ii) scavenging, which converts reactive molecules to harmless products; and (iii) steering, in which the possible formation of a damaged molecule is suppressed. We illustrate the concept of small molecule damage control in plants by describing specific examples for each of these three categories. We highlight interesting insights that we expect future research will provide on those systems, and we discuss promising strategies to discover new small molecule damage-control systems in plants.
ISSN:1559-2316
1559-2324
1559-2324
DOI:10.1080/15592324.2018.1477906