MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma

Members of the miR-125 family are strongly expressed in several tissues, particularly brain, but may be dysregulated in cancer including adult and pediatric glioma. In this study, miR-125 members were downregulated in pilocytic astrocytoma (PA) as a group compared to non-neoplastic brain in the Agil...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-08, Vol.8 (1), p.12506-14, Article 12506
Main Authors: Yuan, Ming, Da Silva, Ana Cristina A. L., Arnold, Antje, Okeke, Laurence, Ames, Heather, Correa-Cerro, Lina S., Vizcaino, M. Adelita, Ho, Cheng-Ying, Eberhart, Charles G., Rodriguez, Fausto J.
Format: Article
Language:English
Subjects:
13
13/106
13/89
38
38/39
631/67/1922
692/53/2421
Apoptosis
Astrocytoma
Brain tumors
Cell growth
Glioma
Glioma cells
Humanities and Social Sciences
miRNA
multidisciplinary
Pediatrics
Science
Science (multidisciplinary)
Senescence
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Members of the miR-125 family are strongly expressed in several tissues, particularly brain, but may be dysregulated in cancer including adult and pediatric glioma. In this study, miR-125 members were downregulated in pilocytic astrocytoma (PA) as a group compared to non-neoplastic brain in the Agilent platform. In the Nanostring platform, miR-125 members were downregulated primarily in pleomorphic xanthoastrocytomas and gangliogliomas. Using CISH for miR-125b, highest levels of expression were present in grade II tumors (11/33, 33% grade II tumors with 3+ expression compared to 3/70, 4% grade I tumors) (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-30942-4