Anthelmintic efficacy of Moringa oleifera seed methanolic extract against Fasciola hepatica

The current study was carried out to assess in vitro and in vivo effects of Moringa oleifera seed methanolic extract on Fasciola hepatica to develop an alternative source of treatment. The in vitro ovicidal effect of M. oleifera seed extract on immature F. hepatica eggs has provided evidence of inhi...

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Bibliographic Details
Published in:Journal of parasitic diseases 2018-09, Vol.42 (3), p.391-401
Main Authors: Kandil, Omnia M., Hassan, Noha M. F., Sedky, Doaa, Ata, Emad B., Nassar, Somia A., Shalaby, Hatem A., Nanev, Veselin, Tsocheva-Gaytandzhieva, Neli, Gabrashanska, Margarita
Format: Article
Language:English
Subjects:
Anthelmintic agents
Cholesterol
Eggs
Fasciola hepatica
Gallbladder
Globulins
Hatchability
Health Promotion and Disease Prevention
Infectious Diseases
Liver
Medicine
Medicine & Public Health
Moringa oleifera
Oral administration
Original
Original Article
Triglycerides
Urea
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Summary:The current study was carried out to assess in vitro and in vivo effects of Moringa oleifera seed methanolic extract on Fasciola hepatica to develop an alternative source of treatment. The in vitro ovicidal effect of M. oleifera seed extract on immature F. hepatica eggs has provided evidence of inhibitory activity on the vitality and hatchability of F. hepatica eggs. This inhibitory activity was concentration-dependent and also correlated strongly with the exposure time. In the in vivo trial, the oral administration of F. hepatica experimentally infected rabbits with doses of 150 mg/kg BW prepared extract per day for 3 consecutive days on the 63rd day post infection confirmed potent fasciolicide activity of the extract. A gradual decrease in fecal egg count (FEC) was detected from the 1st day post treatment until reaching 100% FEC reduction by the 7th day post treatment. No flukes could be found at post mortem examinations. Significant increments of serum total protein, globulin, the activities of ALT and AST, total cholesterol, triglycerides and urea were recorded during the period of infection, which were improved by treatment. Remarkable histopathological alterations were observed in the infected liver and gallbladder tissues which decreased clearly in the treated rabbits. This study proposes that the used extract has promising and potent fasciolicide activity.
ISSN:0971-7196
0975-0703
DOI:10.1007/s12639-018-1014-y