Sex‐specific associations of obesity and N‐terminal pro‐B‐type natriuretic peptide levels in the general population

Background Obese subjects have lower natriuretic peptide levels, but males and females have different anthropometric characteristics and fat distribution. Whether obesity‐associated lowering of natriuretic peptides differs among males and females is unknown. Therefore, we investigated sex‐specific a...

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Bibliographic Details
Published in:European journal of heart failure 2018-08, Vol.20 (8), p.1205-1214
Main Authors: Suthahar, Navin, Meijers, Wouter C., Ho, Jennifer E., Gansevoort, Ron T., Voors, Adriaan A., van der Meer, Peter, Bakker, Stephan J.L., Heymans, Stephane, van Empel, Vanessa, Schroen, Blanche, van der Harst, Pim, van Veldhuisen, Dirk J., de Boer, Rudolf A.
Format: Article
Language:English
Subjects:
Adult
Age
Body Mass Index
Female
Females
Follow-Up Studies
Heart Failure - blood
Heart Failure - etiology
Humans
Incidence
Male
Males
Middle Aged
Natriuretic Peptide, Brain - blood
Netherlands - epidemiology
NT‐proBNP
Obesity
Obesity - blood
Obesity - complications
Obesity - epidemiology
Peptide Fragments - blood
Population Surveillance
Prognosis
Prospective Studies
Risk Factors
Sex
Sex Distribution
Sex Factors
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Summary:Background Obese subjects have lower natriuretic peptide levels, but males and females have different anthropometric characteristics and fat distribution. Whether obesity‐associated lowering of natriuretic peptides differs among males and females is unknown. Therefore, we investigated sex‐specific associations of obesity and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels among adults in the general population. Methods and results Using 8260 participants (50.1% females) from the Prevention of REnal and Vascular ENd‐stage Disease (PREVEND) cohort, we evaluated the relationship of NT‐proBNP levels with obesity‐associated parameters, i.e. waist circumference (WC), body mass index (BMI) and body weight in the overall population, and in males and females separately. NT‐proBNP levels were higher in females (median, interquartile range: 50.5, 28.2–87.0 ng/L) than in males (24.3, 10.1–54.6 ng/L; P 
ISSN:1388-9842
1879-0844
DOI:10.1002/ejhf.1209