Colistin Does Not Potentiate Ceftazidime-Avibactam Killing of Carbapenem-Resistant Enterobacteriaceae In Vitro or Suppress Emergence of Ceftazidime-Avibactam Resistance

We tested ceftazidime-avibactam and colistin against 24 carbapenem-resistant (CRE) isolates by time-kill studies. Ceftazidime-avibactam at 0.25×, 1×, and 4× the MIC was bactericidal against 8%, 21%, and 88% of the isolates, respectively. Colistin (2 μg/ml) was bactericidal against 83% (12 h) and 42%...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-08, Vol.62 (8)
Main Authors: Shields, Ryan K, Nguyen, M Hong, Hao, Binghua, Kline, Ellen G, Clancy, Cornelius J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Azabicyclo Compounds
Carbapenem-Resistant Enterobacteriaceae
Ceftazidime
Colistin
Mechanisms of Resistance
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Summary:We tested ceftazidime-avibactam and colistin against 24 carbapenem-resistant (CRE) isolates by time-kill studies. Ceftazidime-avibactam at 0.25×, 1×, and 4× the MIC was bactericidal against 8%, 21%, and 88% of the isolates, respectively. Colistin (2 μg/ml) was bactericidal against 83% (12 h) and 42% (24 h) of the isolates. In combination, synergy and antagonism were identified against 13% and 46% of the isolates, respectively. The combination did not suppress ceftazidime-avibactam resistance. Colistin plus ceftazidime-avibactam did not provide a benefit over ceftazidime-avibactam against most CRE isolates.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01018-18