Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia

Background. Tuberculosis is a major public health problem and extrapulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis cases worldwide. Objective. To determine the magnitude of EPTB, associated risk factors, and agreement of diagnostic techniques at Dessie Referral Ho...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Gebretsadik, Daniel, Fenta, Genet Mola, Seid, Abdurahaman, Metaferia, Yeshi
Format: Article
Language:English
Subjects:
Assaying
Chronic illnesses
Data processing
Diagnostic systems
Epidemiology
Fluorescence
Health aspects
HIV
Hospitals
Human immunodeficiency virus
Infectious diseases
Laboratories
Lungs
Lymphadenitis
Methylene blue
Microscope and microscopy
Microscopy
Patients
Peritoneum
Public health
Regression analysis
Risk analysis
Risk factors
Smear
Sociodemographics
Statistical analysis
Statistical tests
Studies
Systematic review
Tuberculosis
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Summary:Background. Tuberculosis is a major public health problem and extrapulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis cases worldwide. Objective. To determine the magnitude of EPTB, associated risk factors, and agreement of diagnostic techniques at Dessie Referral Hospital. Methods. A cross-sectional study was conducted on consecutive presumptive EPTB cases from March 1 to June 30, 2017. Sociodemographic characteristics and other variables were collected using a structured questionnaire. Clinical specimens were collected and processed using fluorescent microscopy and Gene Xpert assay. Data was analyzed using SPSS version 20. Chi-square test and logistic regression were done and a P value of ≤0.05 was taken as statistically significant. Results. From a total of 353 presumptive EPTB cases the overall prevalence of Gene Xpert assay and smear confirmed patients was 8.8% and 2.5%, respectively. Tuberculosis lymphadenitis was the predominant (33.3%) type followed by pleural (11.9%) and peritoneal (6.7%) tuberculosis. Previous history of pulmonary tuberculosis was significantly associated with extrapulmonary infection (AOR:2.8; 95%CI: 1.05-7.54; p=0.04); however, other variables such as age, residence, sex, marital status, occupation, level of education, and monthly income did not show any association. Conclusion. High proportions (71%) of Gene Xpert assay confirmed EPTB patients were smear-negative. Sensitivity of microscopy should be enhanced in resource limited countries like Ethiopia where Gene Xpert machine is not easily accessible.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/8207098