Diffuse large B-cell lymphoma with pulmonary and cerebral involvement: A case report

Primary diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma; however, the involvement of the lung and central nervous system (CNS) in patients with DLBCL is rare. Furthermore, patients with DLBCL rarely exhibit specific clinical symptoms, which may delay definitive...

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Bibliographic Details
Published in:Molecular and clinical oncology 2018-09, Vol.9 (3), p.264-268
Main Authors: Zeng, Jing, Zhang, Xiuqun, Hua, Wei, Guo, Caiping, Wu, Hao, Jin, Ronghua, Zhang, Yulin
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antigens
Blood
Bone marrow
Brain tumors
Care and treatment
Case reports
Case studies
Clinical medicine
Complications and side effects
Cytomegalovirus
Dehydrogenases
Development and progression
Fever
HIV
Human immunodeficiency virus
Infections
Laboratories
Lung tumors
Lungs
Lymphoma
Lymphomas
Nervous system
NMR
Nuclear magnetic resonance
Oncology
Patients
Tuberculosis
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Summary:Primary diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma; however, the involvement of the lung and central nervous system (CNS) in patients with DLBCL is rare. Furthermore, patients with DLBCL rarely exhibit specific clinical symptoms, which may delay definitive diagnosis. The present study reports the case of a 42-year-old man suffering from primary DLBCL with concurrent pulmonary and cerebral involvement. The patient suffered from human immunodeficiency virus infection and presented with symptoms including dry cough, thoracalgia, intermittent mild fever and mild headache. Thoracic computed tomography scans revealed multiple pulmonary masses, and brain magnetic resonance imaging scans revealed nodules in the left frontal cortex and bilateral basal ganglia. A percutaneous lung needle biopsy test confirmed the diagnosis of DLBCL. In addition, positron emission tomography revealed the involvement of other parts of the body in DLBCL. The aim of the present study was to present the clinical, radiological and histological characteristics of the patient, which may aid physicians in diagnosing pulmonary and CNS involvement in DLBCL.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2018.1673