Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain

A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but...

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Bibliographic Details
Published in:Brain and neuroscience advances 2018, Vol.2, p.2398212818779646-2398212818779646
Main Authors: Morris, Laurel S., Sprenger, Christian, Koda, Ken, de la Mora, Daniela M., Yamada, Tomomi, Mano, Hiroaki, Kashiwagi, Yuto, Yoshioka, Yoshichika, Morioka, Yasuhide, Seymour, Ben
Format: Article
Language:English
Subjects:
Burrowing behavior
Chronic pain
Cortex (cingulate)
Energy conservation
Factor analysis
Functional magnetic resonance imaging
Hypothalamus
Monkeys & apes
Motivation
Neuroimaging
Nuclei
Pain
Special collection on Prefrontal Cortex
Stria terminalis
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Summary:A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but whether it mediates motivational functions in persistent pain is less clear. Using burrowing behaviour as an marker of non-specific motivated behaviour in rodents, we studied the suppression of burrowing following painful confirmatory factor analysis or control injection into the right knee joint of 30 rats (14 with pain) and examined associated neural connectivity with ultra-high-field resting state functional magnetic resonance imaging. We found that connectivity between anterior cingulate cortex and subcortical structures including hypothalamic/preoptic nuclei and the bed nucleus of the stria terminalis correlated with the reduction in burrowing behaviour observed following the pain manipulation. In summary, the findings implicate anterior cingulate cortex connectivity as a correlate of the motivational aspect of persistent pain in rodents.
ISSN:2398-2128
2398-2128
DOI:10.1177/2398212818779646