HIV-1 Transmissions Among Recently Infected Individuals in Southwest China are Predominantly Derived from Circulating Local Strains

Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introdu...

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Bibliographic Details
Published in:Scientific reports 2018-08, Vol.8 (1), p.12831-9, Article 12831
Main Authors: Li, Jianjun, Feng, Yi, Shen, Zhiyong, Li, Yingxin, Tang, Zhenzhu, Xiong, Runsong, Zhang, Hongman, Wei, Jing, Zhou, Xinjuan, Deng, Yueqin, Fang, Ningye, Lan, Guanghua, Liang, Shujia, Zhu, Qiuying, Xing, Hui, Ruan, Yuhua, Shao, Yiming
Format: Article
Language:English
Subjects:
38/23
38/90
38/91
631/1647/48
631/208/514/1949
692/699/255/1901
Acquired immune deficiency syndrome
AIDS
Bayesian analysis
Disease control
Disease prevention
Disease transmission
Epidemiology
Heroin
HIV
Human immunodeficiency virus
Humanities and Social Sciences
Infections
multidisciplinary
Phylogeny
Pol gene
Science
Science (multidisciplinary)
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Summary:Although the Guangxi region accounts for 10% of all HIV-1 cases new reported in 2011 in China, the sources of the transmitted HIV-1 strains are virtually unknown. To determine the extent to which recent HIV infections were derived from already circulating local strains as opposed to recently introduced strains, we performed a cross-sectional molecular epidemiological investigation of recent infections across Guangxi during 2012–2013. HIV-1 nucleotide sequences were amplified and sequenced. Phylogenetic analyses of pol gene regions were used to determine HIV-1 transmission source strains. Based on 229 sequences generated, the subtype/CRF distribution was as follows: CRF01_AE (61.1%), CRF07_BC (18.8%), CRF08_BC (16.6%), CRF55_01B (3.1%), and subtype B′ (0.4%). In total, 213 of 229 (93.0%) sequenced transmission strains were derived from already-circulating local strains. Multivariate logistic regression analysis showed that only an age of 18–25 years was significantly associated with transmission from outside Guangxi (compared to >25 years, AOR: 5.15, 95% CI: 1.18–22.48, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-29201-3